Fluctuations in plasma dopamine level impair memory in Parkinson's disease.

Author: HuberS J, PaulsonG W, ShulmanH G, ShuttleworthE C

Paper Details 
Original Abstract of the Article :
We found a causal relationship between variation in plasma dopamine level and memory impairment in Parkinson's disease. If the level of dopamine was changed between the time of original learning and a later time of attempted memory retrieval, memory performance was impaired when compared with a main...See full text at original site
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引用元:
https://doi.org/10.1212/wnl.37.8.1371

データ提供:米国国立医学図書館(NLM)

The Shifting Sands of Memory: Dopamine Fluctuations and Memory Impairment in Parkinson's Disease

This research dives into the complex interplay between [dopamine levels] and [memory impairment] in patients with [Parkinson's disease]. It's like exploring the vast desert of the brain, where the researchers seek to understand the delicate balance of neurotransmitters that govern our cognitive functions. The study investigated the causal relationship between [variations in plasma dopamine levels] and [memory performance] in Parkinson's disease.

A Memory Mirage: Fluctuations in Dopamine Disrupt Memory in Parkinson's Disease

The researchers discovered a direct link between [changes in dopamine levels] and [memory impairment] in Parkinson's disease. When the [dopamine levels] fluctuated between the time of learning and memory retrieval, memory performance was significantly impaired. It's like encountering a shimmering mirage in the desert of memory – a temporary illusion that disappears as quickly as it appears. This finding highlights the importance of [stable dopamine levels] for optimal memory function in Parkinson's disease. It’s like finding a steady oasis in the desert of memory – a stable environment is crucial for maintaining cognitive function.

Navigating the Desert of Parkinson's Disease: The Importance of Stable Dopamine Levels

This research underscores the importance of [managing dopamine levels] in [Parkinson's disease] to preserve cognitive function. It emphasizes the potential impact of [fluctuations in dopamine levels] on memory performance, suggesting the need for [therapeutic strategies] that aim to maintain [stable dopamine levels]. It’s like learning to navigate the shifting sands of Parkinson's disease – by understanding the impact of dopamine fluctuations, we can better support patients in their journey.

Dr. Camel's Conclusion

This study provides compelling evidence for the crucial role of dopamine stability in memory function in Parkinson's disease. It highlights the need for therapeutic approaches that prioritize maintaining stable dopamine levels to mitigate memory impairment. The findings suggest that further research is warranted to investigate the specific mechanisms by which dopamine fluctuations impact memory and to develop effective strategies for addressing this challenge. It's like unveiling a new layer of complexity in the desert of Parkinson's disease – a reminder that there's always more to learn about the intricate workings of the brain.
Date :
  1. Date Completed 1987-09-04
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

3614661

DOI: Digital Object Identifier

10.1212/wnl.37.8.1371

Related Literature

SNS
PICO Info
in preparation
Languages

English

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