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Efficacy and safety of miconazole muco-adhesive tablet versus itraconazole in oropharyngeal candidiasis: A randomized, multi-centered, double-blind, phase 3 trial.

Author: ChaiHongbo, ChenQianming, DuanNing, FanYuan, FeiWei, GuanXiaobing, HuaHong, JiaChunling, JiangLu, KongHui, LiuJinli, LiuQing, LuHongzhou, LunWenhui, LuoZhixiao, ShenXuemin, TangGuoyao, WangHongjian, WangWeizhi, WangWenmei, WangYufeng, XuJuanyong, YanZhimin, ZhangTong, ZhaoJizhi, ZhouHaiwen

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This multi-centered, double-blinded, phase III trial found that once-daily treatment with miconazole buccal tablets was non-inferior to itraconazole with higher mycological cure rates and was tolerable with mild adverse events in patients with oropharyngeal candidiasis.
Paper Details　
Original Abstract of the Article :
Oropharyngeal candidiasis (OPC) is an opportunistic infection treated with anti-fungal agents. Herein, we evaluate the efficacy and safety of miconazole buccal tablets (MBT) and itraconazole capsules in the localized treatment of patients with OPC. In this multi-centered, double-blinded, phase III t...See full text at original site
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引用元：
https://doi.org/10.1093/mmy/myac076

データ提供：米国国立医学図書館（NLM）

Combatting Oral Candidiasis: A Journey Through the Desert of Infection

Oral candidiasis, a common fungal infection of the mouth, is like a persistent desert sandstorm, causing discomfort and irritation. This research explores the efficacy and safety of miconazole muco-adhesive tablets (MBT) in treating oropharyngeal candidiasis, seeking a reliable and effective solution for this prevalent condition. The authors conducted a randomized, double-blind, phase III trial, comparing MBT to itraconazole capsules. This research is like a quest through the desert of oral candidiasis, seeking a cure for this persistent ailment.

A New Treatment Option: Miconazole Muco-Adhesive Tablets

This research highlights the potential of MBT as a non-inferior treatment option for oropharyngeal candidiasis. The study demonstrates that MBT achieved comparable clinical cure rates to itraconazole capsules, suggesting a viable alternative for treating this infection. This finding offers a promising new approach to managing oral candidiasis, potentially improving treatment outcomes and patient satisfaction. It's like discovering a new oasis in the desert, providing a refreshing source of relief and healing.

Navigating the Desert of Infection: A Personalized Approach to Care

This research underscores the importance of individualized treatment plans for oral candidiasis. The authors highlight the need to consider each patient's unique symptoms and response to therapy. It's like tailoring a caravan's route to the specific needs of the travelers, ensuring a safe and comfortable journey through the desert. This research emphasizes the importance of collaboration between patients and healthcare professionals in managing this common condition.

Dr. Camel's Conclusion

This research is a testament to the power of scientific innovation in combating oral candidiasis. The discovery of a new and potentially effective treatment option, MBT, offers a glimmer of hope for those struggling with this common infection. This research encourages continued exploration of novel therapies, seeking new and effective ways to navigate the desert of infection and promote oral health.

Date :
  1. Date Completed 2023-09-28
  2. Date Revised 2023-09-28
Further Info :

Pubmed ID

36149321

DOI: Digital Object Identifier

10.1093/mmy/myac076

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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