Paper Details 
Original Abstract of the Article :
Physostigmine (1.5 mg/kg, s.c.) and neostigmine (1.0 mg/kg, s.c.) injection into male mice produced signs of toxicosis characteristic of cholinesterase inhibition and evoked death in 95 and 94% of the animals respectively. Diphenhydramine injections (5-30 mg/kg, s.c.) 15 min before physostigmine or ...See full text at original site
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引用元:
https://doi.org/10.1016/0378-4274(87)90137-8

データ提供:米国国立医学図書館(NLM)

Diphenhydramine and Cholinesterase Inhibitors: A Balancing Act in the Desert of Drug Interactions

This study, like a careful experiment in a desert laboratory, explores the interaction between diphenhydramine, an antihistamine, and cholinesterase inhibitors, medications used to treat conditions like myasthenia gravis. The researchers, like astute scientists, have observed that diphenhydramine can protect mice from the toxic effects of cholinesterase inhibitors. This finding highlights the potential importance of considering drug interactions, especially in the context of complex medication regimens.

Diphenhydramine: A Potential Counterbalance to Cholinesterase Toxicity

The study reveals that diphenhydramine, like a desert oasis offering respite from the harsh sun, can mitigate the toxicity of cholinesterase inhibitors. This suggests that diphenhydramine might have a protective role in certain situations, but further research is needed to confirm its efficacy in humans and determine optimal dosages.

Navigating the Desert of Drug Interactions: A Call for Collaboration

This study underscores the importance of understanding drug interactions and the need for careful monitoring when prescribing medications. It highlights the potential risks of combining certain drugs and the importance of open communication between healthcare providers and patients. This research serves as a reminder that the desert of drug interactions can be treacherous and that vigilance is crucial in ensuring patient safety.

Dr. Camel's Conclusion

This research, like a careful examination of the desert ecosystem, reveals the intricate interplay between drugs and their potential for interaction. Diphenhydramine's protective effect against cholinesterase inhibitor toxicity serves as a reminder of the importance of understanding these interactions and the need for careful consideration in medication regimens. The desert of drug interactions can be complex, but with careful navigation and collaboration, we can ensure patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 1987-09-10
  2. Date Revised 2019-08-19
Further Info :

Pubmed ID

3617097

DOI: Digital Object Identifier

10.1016/0378-4274(87)90137-8

Related Literature

SNS
PICO Info
in preparation
Languages

English

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