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[Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir].

Author: BandoYuki, IshiiHidetoshi, OtoriKatsuya, YokotaNorio

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report discussed the potential for drug interactions between remdesivir (RDV), dexamethasone (DXM), and warfarin (WF) in a patient with COVID-19 and hypertrophic cardiomyopathy. It highlighted the importance of close monitoring of INR levels when co-administering these medications.
Paper Details　
Original Abstract of the Article :
A 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdes...See full text at original site
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引用元：
https://doi.org/10.1248/yakushi.22-00099

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Prolonged INR: A Possible Drug Interaction

This case report examines a patient who experienced [prolonged international normalized ratio (INR)] after receiving [remdesivir] and [dexamethasone] for the treatment of [COVID-19]. The report raises concerns about a potential drug interaction between remdesivir and warfarin, which could contribute to prolonged INR. While further investigation is needed to confirm the specific mechanism of this interaction, the case highlights the importance of careful monitoring and management of drug interactions, especially in patients receiving multiple medications.

Navigating the Complexities of Drug Interactions

This case report illustrates the challenges of managing drug interactions in complex clinical scenarios. It emphasizes the need for close monitoring and vigilance, particularly in patients receiving multiple medications, especially when new drugs are introduced. Healthcare providers must remain alert to potential interactions and adjust treatment strategies accordingly to ensure patient safety.

The Importance of Personalized Medicine and Vigilance

This research underscores the importance of personalized medicine and vigilant monitoring of drug interactions. Healthcare providers must carefully consider the potential risks and benefits of all medications prescribed, particularly in patients receiving multiple therapies. By staying informed about potential drug interactions and taking appropriate precautions, healthcare providers can optimize patient outcomes and ensure their safety.

Dr.Camel's Conclusion

This case report serves as a reminder of the importance of careful drug monitoring and the potential for unexpected interactions. It underscores the need for vigilance in managing complex clinical situations, particularly when multiple medications are involved. As Dr. Camel, I believe that understanding and managing drug interactions is essential for providing safe and effective patient care.

Date :
  1. Date Completed 2022-10-04
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

36184446

DOI: Digital Object Identifier

10.1248/yakushi.22-00099

SNS
PICO Info
in preparation
Languages

Japanese

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