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Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines.
Author: AmosSamson, DuanHuanyun, GrykaRebecca, IstifanJessica, Jean-LouisDenise, LinStacy, ParschauerDaniel, PoweErika, TiwariAmit K
Original Abstract of the Article :
The epidermal growth factor (EGFR) receptor is frequently overexpressed in glioblastoma multiforme IV (GBM). Increased expression of EGFR leads to increased proliferation, decreased apoptosis, and increased resistance to chemotherapeutic agents. A small molecule called erlotinib inhibits EGFR recept...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527275/
データ提供:米国国立医学図書館(NLM)
Luteolin and Erlotinib: A Potential Powerhouse Against Glioblastoma
This research investigates the [combined effects] of [luteolin] and [erlotinib] on [glioblastoma cell lines]. Glioblastoma multiforme (GBM) is a highly aggressive brain cancer that often overexpresses the [epidermal growth factor (EGFR) receptor]. Erlotinib is an FDA-approved drug that targets EGFR, but its effectiveness in treating GBM is limited. This study explores whether combining erlotinib with luteolin, a natural flavonoid, can enhance its anti-cancer activity.
Fighting Glioblastoma: A Promising Combination
The study found that the combination of [luteolin] and [erlotinib] significantly reduced [cell proliferation] and induced [apoptosis] in glioblastoma cell lines. This suggests that combining these two agents may be a more effective treatment strategy than erlotinib alone.
Hope for Brain Cancer: Seeking Expert Opinions
This study's findings offer hope for individuals diagnosed with [glioblastoma]. While more research is needed to translate these findings into clinical practice, the study's results suggest that [combining luteolin with erlotinib] may be a promising new therapeutic approach for GBM. Just as a camel navigates through a challenging desert, scientists are constantly searching for new ways to combat this devastating disease.
Dr. Camel's Conclusion
This research offers a compelling glimpse into the potential of combining luteolin with erlotinib for the treatment of glioblastoma. The study's findings provide a foundation for further exploration and potential clinical applications. Remember, like a camel seeking water in the desert, researchers are dedicated to finding solutions for those facing the challenges of cancer.
Date :
- Date Completed n.d.
- Date Revised 2022-10-07
Further Info :
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