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Evaluation of pharmacological efficacy and safety of hydroxyurea in sickle cell disease: Study of a pediatric cohort from Chhattisgarh, India.

Author: ChandakGiriraj R, LadHarsha, NahrelRakesh, NaskarShoma, PatraPradeep K, Punyasri PasupuletiS K D B, SiharePradeep

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the pharmacological and clinical efficacy and safety of hydroxyurea (HU) in a large pediatric cohort with sickle cell disease (SCD). HU showed beneficial effects on both physical and hematological parameters without any significant adverse effects.
Paper Details　
Original Abstract of the Article :
Sickle cell disease (SCD) is a disease of abnormal hemoglobin associated with severe clinical phenotype and recurrent complications. Hydroxyurea (HU) is one of the US-FDA approved and commonly used drug for the treatment of adult SCD patients with clinical -severity. However, its use in the pediatri...See full text at original site
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引用元：
https://doi.org/10.1080/08880018.2022.2126042

データ提供：米国国立医学図書館（NLM）

Hydroxyurea for Sickle Cell Disease: A Hope for Pediatric Patients

Sickle cell disease (SCD) is a debilitating genetic disorder, and finding effective treatments for children with this condition is a major challenge. This research explores the efficacy and safety of hydroxyurea (HU) in a large pediatric cohort with SCD, providing valuable insights into its potential as a therapeutic option for children.

A Promising Treatment for Pediatric SCD

The study found that HU was well-tolerated and demonstrated significant improvements in both hematological and clinical parameters in children with SCD. The findings highlight the potential of HU to effectively manage the symptoms and complications of SCD in pediatric patients. This research provides a promising foundation for expanding the use of HU in treating children with SCD.

Improving the Lives of Children with SCD

This research offers hope for children living with SCD. The study's findings suggest that HU can effectively manage the symptoms and complications of the disease, improving quality of life and potentially reducing long-term health risks.

Dr. Camel's Conclusion

This research is like a cool oasis in the harsh desert of SCD. The findings provide a ray of hope for children living with this debilitating disease, demonstrating the potential of HU to improve their lives and offer a path towards a healthier future.

Date :
  1. Date Completed 2023-05-02
  2. Date Revised 2023-05-02
Further Info :

Pubmed ID

36226857

DOI: Digital Object Identifier

10.1080/08880018.2022.2126042

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Article Analysis
・Side Effects of hydroxyurea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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