Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.

Author: DarleyCatherine, FahoumMona, FrameJames, HenningMelanie, MinichDeanna M, SchulerCorey B

Paper Details 
Original Abstract of the Article :
Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer's disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined with the COVID-19 pandemic, has led to greater...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571539/

データ提供:米国国立医学図書館(NLM)

Melatonin: The Next Vitamin D?

This research delves into the fascinating world of melatonin, a popular dietary supplement known for its role in regulating sleep cycles. The study utilizes a comprehensive review approach to explore melatonin's potential beyond its chronobiotic function. The authors uncover its antioxidant, immune-boosting, and mitochondrial regulatory capabilities, which are particularly relevant in the context of various diseases like cancer, Alzheimer's, and multiple sclerosis. Intriguingly, melatonin's influence on health mirrors that of vitamin D, both acting as hormones and affecting multiple systems through immune modulation and anti-inflammatory actions. The research also explores the potential link between melatonin deficiency and excessive exposure to artificial blue light, akin to the concern over vitamin D deficiency caused by insufficient sunlight exposure. However, with increased melatonin supplement use, concerns about safety, particularly regarding high doses, long-term use, and its impact on specific populations, have arisen. The authors address these concerns by presenting a thorough analysis of melatonin's mechanisms, clinical applications beyond sleep, safety considerations, and dietary supplementation recommendations. This includes a detailed summary of various melatonin formats, dosage, timing, contraindications, and nutrient combinations.

Melatonin's Impact on Health

The research indicates that melatonin's role in health extends far beyond promoting sleep. Its antioxidant, immune-boosting, and mitochondrial regulatory properties suggest its potential in addressing a wide range of health issues. The study also highlights the striking parallels between melatonin and vitamin D, emphasizing their shared influence on the immune system and anti-inflammatory actions. These findings could have significant implications for the treatment and prevention of chronic diseases.

Melatonin: Navigating the Sands of Supplement Use

While melatonin holds immense promise in various health aspects, the study underscores the importance of cautious supplement use, especially concerning high doses and long-term intake. The authors' thorough analysis provides valuable guidance on melatonin supplementation, including dosage recommendations, appropriate timing, and potential contraindications. Understanding these considerations is crucial for optimizing melatonin's benefits while minimizing any potential risks.

Dr. Camel's Conclusion

As a seasoned researcher who has navigated the vast deserts of scientific knowledge, I find this study's exploration of melatonin's diverse health benefits quite enlightening. The similarities between melatonin and vitamin D are particularly intriguing, highlighting the interconnectedness of our biological systems. This research serves as a valuable roadmap for understanding melatonin's potential applications and navigating the complexities of dietary supplementation. Remember, like a camel navigating a desert, it's essential to approach melatonin supplementation with careful consideration and guidance from healthcare professionals.

Date :
  1. Date Completed 2022-10-17
  2. Date Revised 2022-10-19
Further Info :

Pubmed ID

36235587

DOI: Digital Object Identifier

PMC9571539

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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