A phase II evaluation of temsirolimus with carboplatin and paclitaxel followed by temsirolimus consolidation in clear cell ovarian cancer: An NRG oncology trial.

Author: BirrerMichael J, BonebrakeAlbert, BradyWilliam E, FarleyJohn H, FujiwaraKeiichi, GershensonDavid M, NamJoo-Hyun, O'MalleyDavid, SecordAngeles Alvarez, StephanJean-Marie, WalkerJoan L, YonemoriKan

Paper Details 
Original Abstract of the Article :
OBJECTIVE: The primary objective of the study was to estimate the 12-month progression-free survival (PFS) for carboplatin/paclitaxel + temsirolimus in women with newly diagnosed clear cell ovarian cancer (CCOC), compared to historical controls in this patient population. METHODS: Patients with Sta...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/36244829

データ提供:米国国立医学図書館(NLM)

Targeting Clear Cell Ovarian Cancer: A New Frontier in Treatment

Clear cell ovarian cancer (CCOC), a challenging type of ovarian cancer, often requires innovative treatment approaches. This study explores the potential of a combination therapy involving temsirolimus, carboplatin, and paclitaxel, followed by temsirolimus consolidation, as a promising treatment option for newly diagnosed CCOC. The study aims to evaluate the efficacy and safety of this regimen in treating CCOC, potentially providing a new avenue for managing this complex disease.

A Multifaceted Approach: A New Hope for CCOC Patients

The study provides valuable insights into the efficacy and safety of a combination therapy involving temsirolimus, carboplatin, and paclitaxel for newly diagnosed CCOC. The regimen was well tolerated, and the results suggest that it may be a promising treatment option, particularly for optimally debulked patients. The study underscores the importance of exploring novel treatment approaches to improve outcomes for patients with CCOC.

Navigating the Landscape of CCOC Treatment: A Roadmap for Better Outcomes

This study provides a roadmap for managing CCOC, highlighting the potential benefits of a combination therapy involving temsirolimus, carboplatin, and paclitaxel. The study serves as a valuable resource for clinicians seeking to optimize treatment strategies and improve outcomes for patients with this challenging disease.

Dr.Camel's Conclusion

This study explores the potential of a combination therapy involving temsirolimus, carboplatin, and paclitaxel as a promising treatment option for newly diagnosed CCOC. The study provides valuable insights into the efficacy and safety of this regimen, suggesting that it may be a viable option for managing this complex disease and improving outcomes for patients.

Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2023-12-05
Further Info :

Pubmed ID

36244829

DOI: Digital Object Identifier

NIHMS1856211

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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