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Hepatoprotective effects of carvedilol and crocin against leflunomide-induced liver injury.

Author: Abu-RishaSally El-Sayed, AkoolEl-Sayed, AlkabbaniMahmoud Abdelrahman, SokarSamia Salem

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Carvedilol, a drug used to treat high blood pressure, and crocin, a natural product, were found to protect against liver injury caused by the drug leflunomide. The combination of carvedilol and crocin was more effective than either drug alone.
Paper Details　
Original Abstract of the Article :
Leflunomide-induced liver injury has been an important problem since its approval. Although, severe cases of leflunomide-induced liver injury leading to hospitalization are rare, the risk is higher with concurrent liver disease or use of other hepatotoxic drugs. The current study was conducted to in...See full text at original site
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引用元：
https://doi.org/10.1016/j.intimp.2022.109297

データ提供：米国国立医学図書館（NLM）

A Tale of Two Compounds: Carvedilol and Crocin Combat Leflunomide-Induced Liver Injury

Leflunomide, a drug used to treat rheumatoid arthritis, can sometimes cause liver injury. This study investigates the potential protective effects of carvedilol, a beta-blocker, and crocin, a natural compound found in saffron, against this adverse effect. The researchers conducted an experimental study in mice to evaluate the ability of these compounds to mitigate leflunomide-induced liver damage.

Carvedilol and Crocin: Potential Guardians of Liver Health

The study found that both carvedilol and crocin, alone and in combination, significantly reduced liver injury induced by leflunomide. These compounds effectively protected the liver from damage, suggesting their potential as therapeutic agents for preventing leflunomide-induced hepatotoxicity.

A Hopeful Sign for Liver Health

This research offers a glimmer of hope for patients taking leflunomide. The protective effects of carvedilol and crocin suggest that these compounds may be valuable tools for mitigating the risk of liver damage associated with this medication.

Dr.Camel's Conclusion

You see, even in the vast desert of medical research, there can be hidden treasures - like the potential of carvedilol and crocin to protect the liver. This study shows that even seemingly unrelated compounds can have surprising therapeutic benefits when combined with the right approach.

Date :
  1. Date Completed 2022-12-02
  2. Date Revised 2022-12-02
Further Info :

Pubmed ID

36252480

DOI: Digital Object Identifier

10.1016/j.intimp.2022.109297

Related Literature

Article Analysis
・Effects of leflunomide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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