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Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.

Author: El HamdaouiHalima, ElensLaure, HaufroidVincent, HorionShaleena, HosteEmilia, MuccioliGiulio G, PaninNadtha, PaquotAdrien

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Transporters expressed in muscle tissue play a role in the accumulation of atorvastatin (ATV), which can lead to muscle complaints. Common genetic variations in transporter genes may influence the risk of these side effects.
Paper Details　
Original Abstract of the Article :
Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints. These are difficult to predict owing to high interindividual variability. Such side effects are linked to intramuscular accumulation of ATV. This study aimed to investigate the relative role of transporters express...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168106/

データ提供：米国国立医学図書館（NLM）

Atorvastatin and Muscle Complaints: Unraveling the Role of Transporters

Atorvastatin, a commonly prescribed cholesterol-lowering medication, can sometimes cause muscle-related side effects. This study delves into the mechanisms behind these side effects, focusing on the role of transporters, which act as gatekeepers, controlling the entry and exit of drugs into cells. The researchers explored the impact of genetic variations in two key transporters, SLCO2B1 and ABCC1, on atorvastatin's accumulation in muscle cells.

Navigating the Desert of Drug Transport

The study found that variations in SLCO2B1 and ABCC1 genes can significantly influence atorvastatin's accumulation in muscle cells. This is like navigating a desert with varying terrain, where some paths lead to oasis-like destinations while others end in arid stretches. The study highlights the importance of understanding the role of these transporters in drug delivery and the potential for personalized medicine approaches to minimize the risk of muscle-related side effects.

Understanding Drug Interactions: A Desert Traveler's Guide

This research underscores the importance of considering individual factors when prescribing medications, particularly those that rely on transporter activity. Just as a desert traveler needs to be aware of the terrain, doctors need to be mindful of the potential for drug interactions and individual variability in response to medications. This study encourages a more personalized approach to treatment, ensuring that patients receive the most appropriate and effective care.

Dr.Camel's Conclusion

This study reminds us that the world of drug transport is a complex and fascinating one. By understanding the role of transporters, we can develop more precise and effective treatments that minimize side effects and maximize therapeutic benefits. This is like having a skilled guide who knows the desert terrain and can lead us to the best destinations.

Date :
  1. Date Completed 2023-05-11
  2. Date Revised 2023-08-25
Further Info :

Pubmed ID

36253893

DOI: Digital Object Identifier

PMC10168106

Related Literature

Article Analysis
・Side Effects of atorvastatin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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