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Ameliorating effects of ramelteon on oxidative stress, inflammation, apoptosis, and autophagy markers in methotrexate-induced cerebral toxicity.

Author: AslankocRahime, DoğuçDuygu Kumbul, KaynakMine, SavranMehtap, SevimliMurat, TekinHale

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study aimed to evaluate the possible favorable effects of ramelteon (RMLT) on MTX-induced cerebral toxicity. It finds that RMLT alleviates the harmful effects of MTX on the cerebral cortex tissue. Therefore, RMLT may be considered for supportive therapy for preventing side effects of MTX in patients needing MTX therapy.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Methotrexate (MTX) is a widely used chemotherapeutic agent that, however, is known to have serious side effects such as neurotoxicity. In the present study, we aimed to evaluate the possible favorable effects of ramelteon (RMLT) on MTX-induced cerebral toxicity. MATERIALS AND METHODS: T...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588322/

データ提供：米国国立医学図書館（NLM）

Ramelteon: A Potential Shield Against Methotrexate-Induced Cerebral Toxicity

Methotrexate (MTX), a widely used chemotherapeutic agent, can have serious side effects, including neurotoxicity. This study investigates the potential protective effects of ramelteon (RMLT) against MTX-induced cerebral toxicity. The researchers aimed to evaluate the impact of RMLT on oxidative stress, inflammation, apoptosis, and autophagy markers in a rat model of MTX-induced cerebral toxicity.

Ramelteon: A Potential Neuroprotective Agent

The study revealed that RMLT significantly ameliorated MTX-induced cerebral toxicity in rats. RMLT reversed oxidative stress parameters, reduced autophagy markers, and mitigated inflammatory cell infiltration and apoptotic cell death. These findings suggest that RMLT may have neuroprotective properties, offering potential therapeutic benefits for individuals receiving MTX therapy.

Protecting the Brain During Chemotherapy

This research highlights the importance of mitigating the neurotoxic effects of MTX, a critical concern for individuals undergoing chemotherapy. While further research is needed to confirm these findings in human subjects, RMLT shows promise as a potential supportive therapy for preventing MTX-induced cerebral toxicity. Consulting with a healthcare professional is essential for discussing potential treatment options and managing the side effects of chemotherapy.

Dr.Camel's Conclusion

Navigating the desert of cancer treatment can be a challenging journey, with potential side effects lurking around every corner. This research offers hope for protecting the brain from the harmful effects of MTX. Ramelteon, like a protective shield against the scorching desert sun, demonstrates potential for mitigating neurotoxicity. As always, consulting with a healthcare professional is crucial for personalized treatment strategies and managing the complexities of cancer therapy.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-11-02
Further Info :

Pubmed ID

36311194

DOI: Digital Object Identifier

PMC9588322

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Article Analysis
・Effects of ramelteon・Side Effects of ramelteon
SNS
PICO Info
in preparation
Languages

English

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