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Protective effects of royal jelly and <i>Echinacea</i> against moxifloxacin-induced renal and hepatic injury in rats.

Author: AllamRasha M, MostafaRasha E, ShaffieNermeen M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Royal jelly and echinacea can significantly reduce renal and hepatic injury induced by moxifloxacin, a fluoroquinolone antibiotic, in rats, potentially mitigating the adverse effects of this drug.
Paper Details　
Original Abstract of the Article :
Antibiotic use, especially fluoroquinolones, has been linked to extensive renal and hepatic injury thus inflicts a considerable health problem. Fifty rats were allocated into five groups (<i>n</i>&#8201;=&#8201;10). Group 1 represented the normal-control group. Group 2 received moxifloxacin only (MO...See full text at original site
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引用元：
https://doi.org/10.1080/01480545.2022.2141773

データ提供：米国国立医学図書館（NLM）

Protecting the Desert Oasis: Royal Jelly and Echinacea Against Moxifloxacin-Induced Toxicity

Antibiotics are essential tools in the fight against infections, but their use can sometimes come with unintended consequences. This study investigates the potential protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats. The researchers evaluated the impact of these natural compounds on various biomarkers of renal and hepatic function, as well as on oxidative stress and histopathological changes.

Royal Jelly and Echinacea: A Protective Oasis

The study found that moxifloxacin administration resulted in significant renal and hepatic damage in rats. However, both royal jelly and Echinacea demonstrated protective effects against moxifloxacin-induced toxicity. These natural compounds significantly improved serum parameters of renal and hepatic function, reduced oxidative stress by increasing glutathione levels and decreasing malondialdehyde levels, and ameliorated histopathological changes in the kidneys and liver.

A New Hope for Antibiotic Safety

This research suggests that royal jelly and Echinacea may offer a promising strategy for mitigating the potential toxic effects of moxifloxacin. The findings highlight the importance of exploring natural compounds as potential adjunctive therapies to minimize antibiotic-induced adverse events.

Dr.Camel's Conclusion

This study provides encouraging evidence for the protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic toxicity in rats. The research suggests that these natural compounds may offer a valuable strategy for mitigating antibiotic-induced adverse events and enhancing patient safety.

Date :
  1. Date Completed 2023-09-05
  2. Date Revised 2023-09-05
Further Info :

Pubmed ID

36322409

DOI: Digital Object Identifier

10.1080/01480545.2022.2141773

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PICO Info
in preparation
Languages

English

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