Fulminant Type 1 Diabetes Mellitus Caused by Long-Term Nivolumab Administration Followed by Nivolumab plus Cabozantinib Combination.

Author: EsakiHideki, HommaTakamasa, IsemuraMasaya, KinoshitaTeruhisa, SakakibaraTakashi, TakimotoNorio, TanakaKuniaki, ToriiShota, YoshidaNorio

Paper Details 
Original Abstract of the Article :
Nivolumab, an immune checkpoint inhibitor (ICI), is now used to treat many advanced cancers, including non-small cell lung cancer (NSCLC) and renal cancer. Immune-related adverse events are characteristic side effects of ICIs. Among them, fulminant type 1 diabetes mellitus is an infrequent but poten...See full text at original site
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引用元:
https://doi.org/10.1159/000527541

データ提供:米国国立医学図書館(NLM)

Immune Checkpoint Inhibitors and Diabetes: A Case Report of Fulminant Type 1 Diabetes

This study presents a [case report] that explores the potential link between [immune checkpoint inhibitors] and [fulminant type 1 diabetes]. The authors describe a patient who developed [fulminant type 1 diabetes] following [long-term nivolumab administration] and subsequent treatment with [nivolumab plus cabozantinib]. While the exact role of [cabosantinib] in the development of [diabetes] remains uncertain, the case highlights the need for [caution] and [close glycemic monitoring] in patients receiving [immune checkpoint inhibitor therapy].

The Desert of Immunity: A Case of Diabetes and Immune Checkpoint Inhibitors

The study sheds light on the potential for unexpected side effects from immune checkpoint inhibitors, a class of drugs used to treat cancer. The case highlights the importance of being vigilant about potential complications, such as diabetes, and underscores the need for careful monitoring and management of patients receiving this type of therapy.

Navigating the Shifting Sands of Immunity

Just as the desert landscape can shift and change, the immune system can be unpredictable. This case study serves as a reminder that even seemingly safe medications, like immune checkpoint inhibitors, can have unexpected consequences. It emphasizes the need for continued research and vigilance in understanding the potential impact of these powerful therapies.

Dr.Camel's Conclusion

This case report underscores the importance of continued research and vigilant monitoring in the realm of immune checkpoint inhibitors. It highlights the need for a cautious approach and close monitoring of patients receiving these therapies to minimize the risk of unexpected side effects, such as diabetes.
Date :
  1. Date Completed 2023-02-02
  2. Date Revised 2023-02-02
Further Info :

Pubmed ID

36327909

DOI: Digital Object Identifier

10.1159/000527541

Related Literature

SNS
PICO Info
in preparation
Languages

English

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