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RET Proto-Oncogene-Not Such an Obvious Starting Point in Cancer Therapy.

Author: KalinkaEwa, KowalskiDariusz M, KrawczykPaweł, KubiatowskiTomasz, KucharczykTomasz, PłużańskiAdam

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

RET gene alterations are found in several cancers, including thyroid and lung cancer. While multiple kinase inhibitors (MKIs) have been used, they have limited effectiveness. Recently, two novel RET-specific inhibitors, selpercatinib and pralsetinib, showed high efficacy in clinical trials with fewer adverse effects. However, resistance mutations and activation of signaling pathways can reduce their effectiveness.
Paper Details　
Original Abstract of the Article :
Mutations and fusions of <i>RET</i> (rearranged during transfection) gene are detected in a few common types of tumors including thyroid or non-small cells lung cancers. Multiple kinase inhibitors (MKIs) do not show spectacular effectiveness in patients with <i>RET</i>-altered tumors. Hence, recentl...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657474/

データ提供：米国国立医学図書館（NLM）

RET Proto-Oncogene: A Complex Target in Cancer Therapy

The [treatment of cancers with RET gene alterations] is an ongoing area of research in [oncology]. This review discusses the [molecular mechanisms] involved in [RET gene alterations] and the challenges associated with developing targeted therapies. The authors highlight the importance of [understanding the function of the normal RET receptor] and the [types of molecular disturbances] that can occur in the RET gene. They also discuss the [efficacy of various anticancer therapies], including [kinase inhibitors (MKIs)] and [RET-specific inhibitors]. The review underscores the complexity of targeting the RET gene and the need for further research to develop more effective and durable treatments.

Emerging Strategies for Targeting RET Gene Alterations in Cancer

This review provides a comprehensive overview of the [molecular complexities] associated with [RET gene alterations] in cancer. The authors discuss the [challenges and opportunities] presented by this target and highlight the emergence of [RET-specific inhibitors] as promising therapeutic options. However, the review also emphasizes the need for [continued research] to overcome the challenges of resistance and optimize treatment strategies.

New Hope for Cancer Patients with RET Gene Alterations

This review offers a hopeful glimpse into the future of [cancer treatment] for patients with [RET gene alterations]. The development of [RET-specific inhibitors] represents a significant advancement in targeted therapies. However, it’s important to recognize that [ongoing research] is crucial for addressing the challenges of resistance and ensuring the long-term effectiveness of these treatments.

Dr.Camel's Conclusion

Just as the camel navigates the vast and often unforgiving desert, the journey of treating cancer is long and complex. This review helps us understand the intricacies of RET gene alterations and the emerging strategies for targeting them. The development of RET-specific inhibitors offers a beacon of hope, paving the way for a brighter future for patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-11-17
Further Info :

Pubmed ID

36358717

DOI: Digital Object Identifier

PMC9657474

Related Literature

Article Analysis
・Effects of selpercatinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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