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Pharmacological Interventions for Excessive Daytime Sleepiness in Adults with Narcolepsy: A Systematic Review and Network Meta-Analysis.

Author: ChangYao-Jen, ChienPo-Yu, HungChin-Chuan, KuoChan-Yen, LinMeng-Hsuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A network meta-analysis of 19 RCTs involving 2504 patients with narcolepsy compared the efficacy of various pharmacological interventions for excessive daytime sleepiness (EDS). Solriamfetol showed the highest efficacy in improving EDS, outperforming pitolisant and sodium oxybate. However, pitolisant, sodium oxybate, and modafinil demonstrated more balanced efficacy-safety profiles.
Paper Details　
Original Abstract of the Article :
Narcolepsy is a neurological disease characterized by a core symptom of excessive daytime sleepiness (EDS). Although effective pharmacological interventions for narcolepsy have been developed, a lack of comparative evidence supporting the relative efficacy among these medications leads to clinical t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654433/

データ提供：米国国立医学図書館（NLM）

Narcolepsy: A New Era of Treatment in the Desert of Sleep

The desert of narcolepsy can be a lonely and isolating landscape, where individuals struggle with excessive daytime sleepiness (EDS). This study investigates the efficacy of various pharmacological interventions for narcolepsy, comparing their effectiveness in improving EDS and overall quality of life. This research is like a camel caravan, traversing the desert of sleep disorders, seeking to find the most effective oasis of treatment for those suffering from narcolepsy.

A New Oasis of Treatment: Solriamfetol

The study reveals that solriamfetol emerges as the most effective medication for improving EDS in patients with narcolepsy. It's like discovering a hidden oasis in the desert of sleep disorders, where a powerful and effective solution is found. This research is like a map, guiding us towards a more personalized and effective approach to managing narcolepsy, considering the unique needs of each patient.

Navigating the Desert of Sleep Disorders: A Path to Wellness

This study provides valuable insights into the efficacy of different medications for narcolepsy, offering a roadmap for clinicians to choose the most appropriate treatment for each individual. This research is like a beacon of hope in the desert of sleep disorders, offering a more effective and personalized approach to management. The authors emphasize the need for continued research to explore the long-term benefits and potential side effects of these medications.

Dr.Camel's Conclusion

This study underscores the importance of continued research in the field of narcolepsy, offering a glimmer of hope in the desert of sleep disorders. It's like a wellspring of knowledge, guiding us towards a brighter future for patients seeking relief from EDS. This research is a testament to the unwavering commitment of those who work tirelessly to improve the lives of those living with narcolepsy.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-11-17
Further Info :

Pubmed ID

36362535

DOI: Digital Object Identifier

PMC9654433

SNS
PICO Info
in preparation
Languages

English

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