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Dietary Aspects and Drug-Related Side Effects in Autosomal Dominant Polycystic Kidney Disease Progression.

Author: QuirogaBorja, TorraRoser

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review critically summarizes the evidence on the effect of dietary modification on autosomal dominant polycystic kidney disease (ADPKD) and strategies to mitigate the adverse aquaretic effects of tolvaptan. Moderate sodium restriction, moderate protein intake, and increased water consumption are recommended in ADPKD guidelines.
Paper Details　
Original Abstract of the Article :
Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited kidney disease. In the absence of targeted therapies, it invariably progresses to advanced chronic kidney disease. To date, the only approved treatment is tolvaptan, a vasopressin V2 receptor antagonist that has been...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658114/

データ提供：米国国立医学図書館（NLM）

The Quest for Effective Therapies for Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD), a debilitating genetic disorder, represents a significant challenge in the field of nephrology. This research explores the current landscape of ADPKD management, focusing on the role of dietary modifications and the impact of tolvaptan, the only FDA-approved treatment for this condition. The study aims to provide a comprehensive overview of dietary aspects and drug-related side effects in the progression of ADPKD, highlighting the importance of multi-faceted treatment approaches.

Managing ADPKD: A Balancing Act of Diet and Medications

The study emphasizes the role of dietary modifications, such as moderate sodium restriction, moderate protein intake, and increased water consumption, in mitigating ADPKD progression. While tolvaptan has shown promise in reducing cyst growth, its aquaretic side effects, which lead to frequent urination, pose a significant challenge. The study explores strategies to combat these side effects, including the use of thiazides, metformin, and adjustments in dietary osmotic load.

Living with ADPKD: A Path Towards Healthier Living

This research underscores the importance of a holistic approach to managing ADPKD. By combining dietary modifications with appropriate medical therapies, individuals with ADPKD can strive to slow disease progression and improve their quality of life. This research serves as a valuable resource for patients and clinicians alike, highlighting the potential of personalized management strategies in optimizing outcomes for individuals with this challenging condition.

Dr. Camel's Conclusion

The journey with ADPKD is a long and arduous one, but this research offers valuable insights into the tools available for managing this complex condition. By combining dietary modifications with appropriate medical therapies, individuals with ADPKD can navigate their journey with increased knowledge and a renewed sense of hope.

Date :
  1. Date Completed 2022-11-14
  2. Date Revised 2022-11-17
Further Info :

Pubmed ID

36364911

DOI: Digital Object Identifier

PMC9658114

Related Literature

Article Analysis
・Side Effects of tolvaptan (kidney disease)
SNS
PICO Info
in preparation
Languages

English

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