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The first marine dual-drug cocrystal of cytarabine with 5-fluorouracil having synergistic antitumor effects shows superior biopharmaceutical peculiarities by oral administration.

Author: BuFan-Zhi, LiYan-Tuan, MengSu-Su, WuZhi-Yong, YanCui-Wei, YuYue-Ming

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

ARC-FU cocrystal, a novel crystalline form of cytarabine (ARC) and antitumor drug 5-fluorouracil (FU), has been designed and assembled. The cocrystal has a 1:1 molar ratio of ARC and FU, with FU playing a crucial role in hydrogen bonding formation. The cocrystal exhibits reduced solubility and increased permeability in vitro, leading to extended residence time and enhanced bioavailability in vivo. Moreover, the combination of ARC and FU demonstrates synergistic antitumor effects with lower IC50 values.
Paper Details　
Original Abstract of the Article :
In order to highlight the advantages of cocrystallization technique in perfecting in vitro/vivo natures of marine drug cytarabine (ARC), and fill the gap of the research of marine pharmaceutical cocrystals with synergistic antitumor effects, the first dual-drug cocrystal simultaneously containing AR...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2022.122386

データ提供：米国国立医学図書館（NLM）

Marine Dual-Drug Cocrystal for Cancer Treatment: A New Oasis in the Desert of Chemotherapy

This research explores the potential of a marine dual-drug cocrystal, combining cytarabine (ARC) and 5-fluorouracil (FU), for cancer treatment. It's like discovering a new oasis in the desert of chemotherapy, with a potent combination of resources to combat cancer cells. The study demonstrates that this cocrystal exhibits enhanced properties, including reduced solubility, increased permeability, and prolonged residence time, potentially leading to improved therapeutic efficacy.

A Synergistic Approach to Cancer Treatment

The study found that the ARC-FU cocrystal exhibits synergistic antitumor effects, meaning that the two drugs work together more effectively than they would individually. It's like a camel caravan working together to navigate the desert – a combined effort leads to greater success.

A Camel's Guide to Cancer Treatment

This research highlights the innovative potential of cocrystallization technology for developing new and improved cancer treatments. It's like finding a hidden oasis that offers a fresh perspective and powerful new tools.

Dr. Camel's Conclusion

This study showcases the remarkable possibilities of marine drug cocrystals for cancer treatment. It's a testament to the ever-evolving landscape of cancer research, with new oases of hope emerging to combat this formidable disease.

Date :
  1. Date Completed 2022-12-02
  2. Date Revised 2022-12-02
Further Info :

Pubmed ID

36372139

DOI: Digital Object Identifier

10.1016/j.ijpharm.2022.122386

Related Literature

Article Analysis
・Effects of cytarabine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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