Pralsetinib in RET fusion-positive non-small-cell lung cancer: A real-world data (RWD) analysis from the Italian expanded access program (EAP).

Author: AttiliIlaria, BertoliniFederica, BonannoLaura, BonomiLucia, CartaAnnamaria, CecereFabiana, D'ArcangeloManolo, GenovaCarlo, GiustiRaffaele, GrisantiSalvatore, GuaitoliGiorgia, LuginiAntonio, MassaGiacomo, MetroGiulio, MontroneMichele, PassaroAntonio, PassigliaFrancesco, PerroneFabiana, RussanoMarco, RussoGiuseppe Lo, SbranaAndrea, ScottiVieri, SimionatoFrancesca, de MarinisFilippo

Paper Details 
Original Abstract of the Article :
OBJECTIVES: The selective RET-inhibitor pralsetinib has shown therapeutic activity in early clinical trials in patients with non-small cell lung cancer (NSCLC) harboring rearranged during transfection (RET) gene fusions. To date, the real-world efficacy of pralsetinib in this population is unknown. ...See full text at original site
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引用元:
https://doi.org/10.1016/j.lungcan.2022.11.005

データ提供:米国国立医学図書館(NLM)

Pralsetinib in RET Fusion-Positive Non-Small-Cell Lung Cancer: Real-World Data Analysis

This study dives into the world of non-small cell lung cancer (NSCLC) and explores the effectiveness of a new targeted therapy, pralsetinib, in patients with a specific genetic mutation known as RET fusion. The researchers analyzed real-world data from a large cohort of Italian patients with RET fusion-positive NSCLC who received pralsetinib. The study found that pralsetinib demonstrated significant therapeutic activity in this patient population, achieving impressive response rates and disease control. The researchers also examined the safety profile of the drug and found that it was generally well-tolerated, with manageable side effects.

Pralsetinib Shows Promise in Real-World Setting

This study provides encouraging evidence that pralsetinib can effectively target RET fusion-positive NSCLC, achieving significant response rates and disease control in a real-world setting. This finding highlights the potential of targeted therapies in the fight against cancer. It's like finding a specific antidote to a poison, offering a targeted solution to a complex problem.

What Does This Mean for You?

This research offers hope for patients with RET fusion-positive NSCLC, demonstrating the potential of pralsetinib to be an effective treatment option. While further research is always ongoing, these findings suggest that pralsetinib can offer a meaningful improvement in the lives of patients with this specific type of lung cancer. Remember, staying informed and working closely with your healthcare team is essential for navigating any health challenge, just as a camel navigates a desert landscape with knowledge of the terrain.

Dr.Camel's Conclusion

This study underscores the power of personalized medicine, demonstrating the effectiveness of targeted therapies in treating specific genetic mutations in cancer. It's a testament to the advancements in our understanding of cancer biology and the potential of precision medicine to revolutionize treatment approaches. Just as a camel navigates a desert using its unique adaptations, medicine is increasingly finding targeted solutions to address the complexities of disease.

Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

36379124

DOI: Digital Object Identifier

10.1016/j.lungcan.2022.11.005

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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