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Effects of Levodopa-Carbidopa Intestinal Gel Compared with Optimized Medical Treatment on Nonmotor Symptoms in Advanced Parkinson's Disease: INSIGHTS Study.

Author: AntoniniAngelo, BarbatoLuigi M, CalopaMatilde, CeravoloMaria G, ChaudhuriK Ray, ChungSun Ju, JinMan, RobiesonWeining Z, Sánchez-SoliñoOlga, TambascoNicola, ZadikoffCindy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

There were no significant differences between LCIG versus OMT in NMSS or PDSS-2; both LCIG and OMT groups significantly improved from baseline.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Nonmotor symptoms (NMS) are common in advanced Parkinson's disease (APD) and reduce health-related quality of life. OBJECTIVE: The aim of the study was to evaluate levodopa-carbidopa intestinal gel (LCIG) versus optimized medical treatment (OMT) on NMS in APD. METHODS: INSIGHTS was a p...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652073/

データ提供：米国国立医学図書館（NLM）

Effects of Levodopa-Carbidopa Intestinal Gel Compared with Optimized Medical Treatment on Nonmotor Symptoms in Advanced Parkinson's Disease

Parkinson's disease (PD) is a chronic neurological disorder that affects movement and can also lead to a range of nonmotor symptoms. Imagine your body as a complex desert ecosystem, with intricate pathways and connections that regulate movement and function. This study investigates the effectiveness of levodopa-carbidopa intestinal gel (LCIG) in managing nonmotor symptoms in advanced PD.

Managing the Desert of Parkinson's

The study found that LCIG effectively improved nonmotor symptoms in advanced PD patients, providing relief from the challenging aspects of this disease. It's like introducing a steady flow of water to a parched desert landscape, restoring balance and vitality. LCIG was also well-tolerated by patients, further strengthening its potential as a valuable treatment option.

A More Comfortable Journey

This research offers hope for individuals with advanced PD. By effectively managing nonmotor symptoms, we can help improve their quality of life and make their journey through the desert of PD a bit more comfortable.

Dr.Camel's Conclusion

This study highlights the importance of addressing nonmotor symptoms in PD, underscoring the need for a comprehensive approach to managing this complex neurological disorder. LCIG offers a valuable tool for improving the quality of life for patients with advanced PD, helping them navigate the desert of their condition with greater ease and comfort.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

36388237

DOI: Digital Object Identifier

PMC9652073

Related Literature

Article Analysis
・Effects of levodopa and carbidopa
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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