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Anticoagulant effects of rivaroxaban, prednisone, alone and in combination, in healthy dogs.

Author: BrooksMarjory B, HafnerPaige M, MackinAndrew J, ThomasonJohn M, WillsRobert W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Prednisone administration had no apparent influence on the anticoagulant effects of rivaroxaban in healthy dogs, suggesting that combined therapy will not require dosage adjustments. Clotting times in the prothrombin time (PT) correlated with rivaroxaban levels and may be useful for drug monitoring.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The potential effects of glucocorticoid administration on rivaroxaban's anticoagulant bioactivity in dogs, and an appropriate rivaroxaban dosage regimen for dogs receiving glucocorticoid therapy are unknown. HYPOTHESIS/OBJECTIVES: The objective was to determine whether glucocorticoid ad...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708426/

データ提供：米国国立医学図書館（NLM）

Rivaroxaban and Prednisone: A Study of Anticoagulant Effects in Dogs

This study investigates the potential interaction between rivaroxaban, a commonly used anticoagulant, and prednisone, a glucocorticoid, in dogs. The researchers conducted a randomized cross-over study to evaluate the anticoagulant effects of rivaroxaban alone and in combination with prednisone.

No Significant Interaction Between Rivaroxaban and Prednisone

The study found no significant difference in the anticoagulant intensity of rivaroxaban when administered alone or in combination with prednisone. This suggests that prednisone does not appear to influence the anticoagulant effects of rivaroxaban in healthy dogs.

Understanding Drug Interactions

This research provides valuable insights into the potential for drug interactions, particularly in the context of anticoagulant therapy. The study's findings suggest that prednisone administration may not require dosage adjustments for rivaroxaban in dogs. As Dr. Camel, I am always mindful of the importance of understanding drug interactions to ensure patient safety.

Dr.Camel's Conclusion

This study provides reassuring evidence that prednisone does not appear to significantly affect the anticoagulant effects of rivaroxaban in dogs. The findings suggest that combined therapy with rivaroxaban and prednisone may not require dosage adjustments.

Date :
  1. Date Completed 2022-12-01
  2. Date Revised 2022-12-03
Further Info :

Pubmed ID

36399000

DOI: Digital Object Identifier

PMC9708426

Related Literature

Article Analysis
・Effects of rivaroxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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