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In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects.

Author: AjdukovićJovana J, MarinovićMaja A, PetriEdward T, SavićMarina P, ŠestićTijana Lj

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study utilized in silico ADMET models to predict the pharmacokinetic and drug-like properties of androstane derivatives with potent anticancer activity. The analysis focused on their absorption, distribution, metabolism, and excretion (ADME) profiles. Two compounds with promising ADMET results and cytotoxicity were identified as potential candidates for further in vivo evaluation, suggesting their potential as novel anticancer agents.
Paper Details　
Original Abstract of the Article :
The major challenge in the fight against cancer is to design new drugs that will be more selective for cancer cells, with fewer side effects. Synthetic steroids such as cyproterone, fulvestrant, exemestane and abiraterone are approved powerful drugs for the treatment of hormone-dependent diseases su...See full text at original site
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引用元：
https://doi.org/10.1016/j.steroids.2022.109147

データ提供：米国国立医学図書館（NLM）

Androstane Derivatives: Potential Anticancer Agents with Favorable ADMET Properties

The fight against cancer is a constant quest for new and effective treatments. This study explores the potential of androstane derivatives, a class of synthetic steroids, as anticancer agents. The researchers used in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis to predict the pharmacokinetic properties of these derivatives. They identified several compounds with promising anticancer activity and favorable ADMET profiles, suggesting their potential for further development as drug candidates.

Promising Candidates for Cancer Treatment

This study offers a promising step forward in the search for new anticancer agents. The identification of androstane derivatives with favorable ADMET properties opens the door for further research and development of these compounds as potential treatments for cancer.

The Promise of Personalized Medicine

The development of new cancer treatments is crucial for improving patient outcomes. This research highlights the potential of personalized medicine, where treatments are tailored to the individual patient's needs, based on their unique genetic and molecular characteristics. This approach could lead to more effective and targeted therapies, improving the chances of successful treatment.

Dr.Camel's Conclusion

This research is a testament to the tireless efforts of scientists working to find new and effective treatments for cancer. The identification of androstane derivatives with promising anticancer activity and favorable ADMET profiles offers hope for the future of cancer treatment.

Date :
  1. Date Completed 2022-12-30
  2. Date Revised 2023-02-16
Further Info :

Pubmed ID

36410412

DOI: Digital Object Identifier

10.1016/j.steroids.2022.109147

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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