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Role of topical spironolactone in the treatment of acne: A systematic review of clinical trials-Does this therapy open a path towards favorable outcomes?

Author: AbbasSamina, AhmedAli, EljackMohammed Mahmmoud Fadelallah, ImranLaiba, KhanZayeema, KheljeeAqib Zaman, MunirSaqib, RehanSyeda Tayyaba, TahirMuhammad Junaid

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This systematic review investigated the efficacy and safety of topical spironolactone for acne treatment. It found that topical spironolactone significantly reduced acne lesions and was more effective than some first-line treatments with fewer side effects. However, larger studies are needed to confirm its efficacy and establish it as a preferred treatment option.
Paper Details　
Original Abstract of the Article :
Acne vulgaris is the eighth most common disease worldwide and presents with inflammatory and noninflammatory skin lesions along with other dermal abnormalities. Oral spironolactone is used for treating acne vulgaris due to its antiandrogenic properties and inhibition of sebogenesis. Recent evidence ...See full text at original site
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引用元：
https://doi.org/10.1111/1346-8138.16637

データ提供：米国国立医学図書館（NLM）

Topical Spironolactone for Acne: A Promising Treatment Option

Acne vulgaris is a common skin condition. Oral spironolactone is a known treatment due to its antiandrogenic properties. This systematic review investigates the efficacy and safety of topical spironolactone in treating acne vulgaris. The review included five clinical trials with 195 patients. The review found that patients treated with topical spironolactone showed a significant decrease in the number of papules, closed comedones, and lesions. Topical spironolactone was more effective than other first-line treatments for acne and showed fewer side effects. The review concludes that further large-scale clinical trials are needed to confirm the efficacy and safety of topical spironolactone before it can be used as a preferred treatment for acne.

Topical Spironolactone: A New Hope for Acne Treatment

This systematic review provides encouraging evidence for the efficacy of topical spironolactone in treating acne vulgaris. The findings suggest that topical spironolactone could be a promising alternative to oral spironolactone and other first-line acne treatments.

The Desert of Acne: Finding a Remedy

Acne can be a frustrating and persistent skin condition. This review offers hope for a new and effective treatment option. The research highlights the importance of exploring new avenues for treating acne and improving patient outcomes.

Dr.Camel's Conclusion

This systematic review provides evidence for the efficacy and safety of topical spironolactone in treating acne vulgaris. The findings suggest that topical spironolactone could be a promising treatment option, offering a more convenient and potentially safer alternative to oral spironolactone. Further large-scale clinical trials are needed to confirm these findings and establish topical spironolactone as a preferred treatment for acne.

Date :
  1. Date Completed 2023-02-03
  2. Date Revised 2023-02-03
Further Info :

Pubmed ID

36412248

DOI: Digital Object Identifier

10.1111/1346-8138.16637

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・Side Effects of spironolactone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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