Dasatinib for treatment of CAR T-cell therapy-related complications.

Author: BaurKatharina, BeerlageAstrid, DirksJan C, HeimDominik, HolbroAndreas, KoppBastian, MedingerMichael, PasswegJakob R, PoeringsAnna S

Paper Details 
Original Abstract of the Article :
Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are severe, potentially life-threatening side effects of chimeric antigen receptor T-cell (CAR T) therapy caused by the release of cytokines by proliferating and activated CAR T-cells. Current mainstay...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717332/

データ提供:米国国立医学図書館(NLM)

Dasatinib: A Potential Oasis in the Desert of CAR T-Cell Therapy Complications

The world of [CAR T-cell therapy] is constantly evolving, and with it comes new challenges. One such challenge is the occurrence of [cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS)]. This study investigates the potential of [dasatinib], a tyrosine kinase inhibitor, as a treatment for these potentially life-threatening complications. The researchers report a case where [dasatinib] successfully treated a patient with [grade 3 CRS and grade 4 ICANS] refractory to standard therapies, suggesting a potential new weapon in the fight against these complications.

Navigating the Sands of CAR T-Cell Therapy: A New Hope?

The study suggests that [dasatinib] could be a valuable addition to the therapeutic arsenal for managing [CAR T-cell therapy-related complications]. While further studies are needed, these findings offer a glimmer of hope for patients facing the challenges of [CRS and ICANS].

Living in the Oasis: Managing CAR T-Cell Therapy

The use of [CAR T-cell therapy] is still relatively new, and there is much we still need to learn about its long-term effects. It's important to have open communication with your healthcare provider and to be aware of the potential risks and benefits of this therapy. The ongoing research in this area is promising, and we can look forward to a future where [CAR T-cell therapy] becomes a safe and effective treatment option for a wider range of patients.

Dr.Camel's Conclusion

The desert of [CAR T-cell therapy] is a vast and complex landscape, but this study highlights the potential of [dasatinib] to provide a safe haven for patients facing [CRS and ICANS]. While the journey towards safe and effective management of these complications continues, this research offers a valuable step forward.

Date :
  1. Date Completed 2022-12-06
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

36455991

DOI: Digital Object Identifier

PMC9717332

Related Literature

SNS
PICO Info
in preparation
Languages

English

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