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Metronidazole and Peripheral Neuropathy: A Report of Two Cases of (Unusual) Side Effects.

Author: ArigoniMichele, CelioDiana, GussagoStefano, Poroli BastoneCristiana, QuarenghiMassimo C

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Metronidazole, a commonly prescribed antibiotic, can cause peripheral neuropathy. This report describes two cases of peripheral neuropathy attributed to metronidazole treatment. Prolonged therapy regimens (>4 weeks of treatment and/or 42 g cumulative dose) may increase the risk of neurological complications, particularly peripheral polyneuropathy.
Paper Details　
Original Abstract of the Article :
Metronidazole is an antibiotic commonly prescribed for anaerobic and protozoan infections. Despite its good safety profile, this drug frequently causes a series of well-known side effects (nausea and intestinal transit disorders, dysgeusia, headaches, and alcohol intolerance). However, there are few...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709505/

データ提供：米国国立医学図書館（NLM）

Metronidazole: Exploring the Potential for Peripheral Neuropathy

Metronidazole, a commonly prescribed antibiotic for anaerobic and protozoan infections, generally has a good safety profile. This study explores the potential for metronidazole to cause peripheral neuropathy, a debilitating neurological condition characterized by numbness, tingling, and pain in the extremities.

Metronidazole: A Rare Side Effect

The researchers present two case reports of patients who developed peripheral neuropathy after receiving metronidazole therapy. While peripheral neuropathy is a rare side effect of metronidazole, the study emphasizes the importance of being aware of this potential complication, especially in patients receiving prolonged or high-dose treatment. The study suggests that prolonged therapy regimens, particularly those exceeding 4 weeks and cumulative doses of 42 g, may increase the risk of developing neurological complications.

Metronidazole: Navigating the Desert of Side Effects

This research highlights the importance of understanding the potential side effects of medications, even those commonly used and generally considered safe. While peripheral neuropathy is a rare side effect of metronidazole, it is essential for healthcare professionals to be aware of this potential complication and to monitor patients closely, particularly those receiving prolonged or high-dose treatment. This research provides a valuable reminder to tread cautiously through the desert of potential side effects, ensuring patient safety and well-being.

Dr.Camel's Conclusion

This study reminds us that even commonly used medications can have rare but potentially serious side effects. While peripheral neuropathy is a rare side effect of metronidazole, it is crucial for healthcare professionals to be aware of this potential complication and to monitor patients closely, especially those receiving prolonged or high-dose treatment. This research reinforces the importance of vigilant monitoring and careful consideration of potential side effects when prescribing medications.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-06
Further Info :

Pubmed ID

36465791

DOI: Digital Object Identifier

PMC9709505

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Article Analysis
・Side Effects of metronidazole
SNS
PICO Info
in preparation
Languages

English

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