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Effects of Different Opioid Drugs on Oxidative Status and Proteasome Activity in SH-SY5Y Cells.

Author: CandelettiSanzio, CanistroDonatella, CaputiFrancesca Felicia, LosapioLoredana Maria, MorosiniCamilla, PosaLuca, RomualdiPatrizia, RulloLaura, VivarelliFabio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of morphine, buprenorphine, and tapentadol on intracellular reactive oxygen species (ROS) levels, superoxide dismutase (SOD) activity/gene expression, and proteasome function in SH-SY5Y cells. The results show that these opioids differentially affect ROS production, SOD function, and proteasome activity/biosynthesis, suggesting a potential link between these cellular processes and opioid-related side effects.
Paper Details　
Original Abstract of the Article :
Opioids are the most effective drugs used for the management of moderate to severe pain; however, their chronic use is often associated with numerous adverse effects. Some results indicate the involvement of oxidative stress as well as of proteasome function in the development of some opioid-related...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738452/

データ提供：米国国立医学図書館（NLM）

Understanding the Impact of Opioids on Cellular Health

The world of pain management is constantly searching for safer and more effective approaches. This study investigates the effects of various opioid drugs on the delicate balance of cellular processes, particularly oxidative stress and proteasome activity. The research aims to shed light on the mechanisms behind opioid-related side effects, such as analgesic tolerance and dependence.

Opioids: A Complex Dance with the Body

This study provides valuable insights into the diverse impact of different opioids on cellular functions. The research shows that while some opioids, such as morphine, can disrupt the delicate balance of oxidative stress, others, like buprenorphine and tapentadol, may have a less disruptive effect. This information emphasizes the importance of personalized approaches to opioid management, considering the specific effects of each drug on the individual patient.

Balancing Pain Relief and Cellular Harmony

This research is like a map leading us through the intricate landscape of opioid use. The study helps us understand the potential impact of these drugs on cellular processes, enabling us to make informed decisions about pain management. Remember, as with any medication, it's crucial to consult with your doctor to discuss your individual needs and risks.

Dr.Camel's Conclusion

This study, like a compass guiding us through the complexities of opioid use, helps us understand how these medications interact with our cellular processes. The findings highlight the importance of individualizing treatment approaches to minimize potential risks and maximize therapeutic benefits.

Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

36500414

DOI: Digital Object Identifier

PMC9738452

Related Literature

Article Analysis
・Side Effects of tapentadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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