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Adverse Events Associated with Universal versus Targeted Antifungal Prophylaxis among Lung Transplant Recipients-A Nationwide Cohort Study 2010-2019.

Author: ArendrupMaiken Cavling, BredahlPia, CroneCornelia Geisler, HellebergMarie, Helweg-LarsenJannik, PerchMichael, WulffSigne Marie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Universal voriconazole prophylaxis for invasive fungal infections in lung transplant (LTX) recipients was associated with high discontinuation rates due to hepatotoxicity, and increased rates of low calcineurin inhibitor (CNI) levels and acute rejection compared to targeted posaconazole prophylaxis. The study suggests that a targeted approach to prophylaxis may be more effective and safer for LTX recipients.
Paper Details　
Original Abstract of the Article :
Background: Invasive fungal infections in lung transplant (LTX) recipients cause substantial morbidity, but the best strategy for prevention has not yet been determined. We evaluated adherence to and rates of adverse events of universal versus targeted prophylaxis. Methods: All LTX recipients in the...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787947/

データ提供：米国国立医学図書館（NLM）

A New Oasis in the Desert of Lung Transplant Prophylaxis

[Invasive fungal infections] are a significant threat to [lung transplant (LTX)] recipients, making prophylaxis a critical aspect of post-transplant care. This study examines the use of [universal] versus [targeted antifungal prophylaxis] in [LTX] recipients, like finding the best oasis in a desert of potential dangers. The study found that [universal voriconazole prophylaxis] was associated with a higher rate of [discontinuation due to hepatotoxicity] and higher rates of [low CNI levels] and [acute rejection] compared to [targeted posaconazole prophylaxis]. This suggests that [targeted antifungal prophylaxis] may be a more effective approach to preventing [invasive fungal infections] in [LTX] recipients.

Targeted Prophylaxis: A More Effective Oasis?

The results of this study suggest that [targeted antifungal prophylaxis] may be a more effective strategy for preventing [invasive fungal infections] in [LTX] recipients. The findings highlight the potential benefits of tailoring treatment to individual risk factors.

Navigating the Desert of Lung Transplant Care

This study provides valuable insights for healthcare providers involved in [lung transplant] care. It highlights the need to carefully weigh the risks and benefits of different prophylactic strategies to ensure the best outcomes for their patients.

Dr.Camel's Conclusion

The desert of [lung transplant] care is a challenging landscape, but this study helps to identify a potentially safer and more effective oasis in the form of [targeted antifungal prophylaxis]. This research is a valuable contribution to the field, offering new insights into the management of [invasive fungal infections] in [LTX] recipients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-08
Further Info :

Pubmed ID

36557731

DOI: Digital Object Identifier

PMC9787947

SNS
PICO Info
in preparation
Languages

English

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