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Specific Inhibition of Interpeduncular Nucleus GABAergic Neurons Alleviates Anxiety-Like Behaviors in Male Mice after Prolonged Abstinence from Methamphetamine.

Author: FanYu, GeFeifei, GuanXiaowei, HeTeng, LiNanqin, LuXue, WangZilin, WenJun, XuBo, XuXing, YangPing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prolonged abstinence from methamphetamine (METH) can lead to increased anxiety-like behaviors in mice, linked to increased excitability of GABAergic neurons in the interpeduncular nucleus (IPN). Specific inhibition of IPN GABAergic neurons reduced anxiety-like behaviors in mice after prolonged METH abstinence, suggesting a promising target for alleviating withdrawal symptoms.
Paper Details　
Original Abstract of the Article :
Anxiety is one of the most common withdrawal symptoms of methamphetamine (METH) abuse, which further drives relapse to drugs. Interpeduncular nucleus (IPN) has been implicated in anxiety-like behaviors and addiction, yet its role in METH-abstinence-induced anxiety remains unknown. Here, we found tha...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899084/

データ提供：米国国立医学図書館（NLM）

Targeting Anxiety in Methamphetamine Withdrawal: A New Role for Interpeduncular Nucleus GABAergic Neurons

Methamphetamine (METH) addiction poses a significant public health challenge. This research explores the role of the interpeduncular nucleus (IPN) in anxiety-like behaviors during METH withdrawal. The study investigates the activity of GABAergic neurons in the IPN and their potential as a therapeutic target for reducing withdrawal anxiety.

The Interpeduncular Nucleus: A Key Player in Anxiety and Addiction

This research reveals that prolonged abstinence from METH leads to increased anxiety-like behaviors and heightened excitability of GABAergic neurons in the IPN. The study demonstrates that selectively inhibiting these neurons can alleviate anxiety-like behaviors without inducing depression-like behaviors.

A New Hope for Managing Methamphetamine Withdrawal

This research offers promising insights into the potential for targeting specific brain regions to manage the debilitating symptoms of METH withdrawal. The findings suggest that the IPN could be a valuable therapeutic target for reducing anxiety and improving the well-being of individuals recovering from METH addiction.

Dr.Camel's Conclusion

This study sheds light on a novel therapeutic target for managing the anxiety associated with METH withdrawal. Targeting IPN GABAergic neurons holds promise for developing effective treatments for this challenging condition.
Date :
  1. Date Completed 2023-02-03
  2. Date Revised 2023-08-02
Further Info :

Pubmed ID

36564185

DOI: Digital Object Identifier

PMC9899084

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Languages

English

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