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Synergistic effect of pyrvinium pamoate and posaconazole against <i>Cryptococcus neoformans in vitro</i> and <i>in vivo</i>.

Author: ChenMin, FangHong, LiSheng, LiYali, XiaoJialing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the antifungal effects of pyrvinium pamoate (PP) alone and in combination with various azoles (fluconazole, itraconazole, voriconazole, posaconazole) or amphotericin B against *Cryptococcus neoformans* in vitro and in vivo. The results suggest that PP exhibits fungistatic effects both individually and synergistically when combined with other antifungal agents.
Paper Details　
Original Abstract of the Article :
Label="Background">Cryptococcosis is a global invasive mycosis with high rates of morbidity and mortality, especially in AIDS patients. Its treatment remains challenging because of the limited antifungals and their unavoidable toxicity, and as such more efforts need to focus on the development of no...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780465/

データ提供：米国国立医学図書館（NLM）

Cryptococcosis: A Challenging Mycosis

The field of infectious diseases is constantly evolving, and one of the most pressing challenges is the treatment of cryptococcosis, a fungal infection that can be life-threatening, especially for individuals with weakened immune systems. This study delves into the exciting potential of pyrvinium pamoate (PP), a drug already known for its antifungal properties. The researchers explored the synergistic effects of PP when combined with other antifungal drugs, such as fluconazole, itraconazole, voriconazole, posaconazole, and amphotericin B, against the fungus Cryptococcus neoformans both in the lab and in living organisms. The research team aimed to determine whether this combination strategy could lead to more effective treatment options with potentially fewer side effects. Their results indicate that PP, when used in conjunction with other antifungal agents, may offer a new approach to combat this challenging infection.

Synergistic Effects: A Powerful Combination

The study's findings suggest that combining PP with other antifungal agents, such as posaconazole, can create a synergistic effect, meaning that the combined effect is greater than the sum of the individual effects of each drug. This finding could lead to the development of more potent antifungal therapies with the potential to improve treatment outcomes for patients with cryptococcosis.

Combating Infections with Precision

This research offers a glimmer of hope for patients battling cryptococcosis. The potential of PP, in combination with other antifungals, to effectively target this stubborn fungus could revolutionize treatment strategies and ultimately improve the lives of countless individuals.

Dr.Camel's Conclusion

This study is like a camel caravan crossing the vast desert of fungal infections. PP is like a new oasis, offering a promising new approach to combating cryptococcosis. The synergistic effects of PP combined with other antifungal agents may lead to more effective treatments with potentially fewer side effects.

Date :
  1. Date Completed 2022-12-27
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

36569209

DOI: Digital Object Identifier

PMC9780465

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・Effects of posaconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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