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Myasthenia gravis, myositis and myocarditis: a fatal triad of immune-related adverse effect of immune checkpoint inhibitor treatment.
Author: DiasMaria Cecilia, KardosAttila, RizviSyed Azhar J, SomanBiji
Original Abstract of the Article :
Pembrolizumab, a humanised monoclonal antibody and immune checkpoint inhibitor (ICI) that blocks programmed death receptor 1 and its ligands, is an effective immunotherapy for malignancies such as melanoma, lung, head and neck, cancers, and Hodgkin's lymphoma. It has an overall response rate between...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743272/
データ提供:米国国立医学図書館(NLM)
Immune Checkpoint Inhibitors: A Triad of Potential Complications
This case report highlights a rare and potentially life-threatening triad of immune-related adverse effects associated with immune checkpoint inhibitor (ICI) treatment. The authors present a case of a woman with non-small-cell lung cancer who developed myasthenia gravis, myocarditis, and myositis after receiving pembrolizumab, a type of ICI. This combination of complications proved resistant to medical intervention and ultimately led to a fatal outcome. This case report emphasizes the importance of being aware of the potential for severe and even fatal complications associated with ICI therapy, advocating for careful monitoring and early intervention to prevent adverse events.
Navigating the Desert of Immunotherapy: A Cautious Approach
This case report serves as a stark reminder of the potential risks associated with immunotherapy, highlighting the need for a cautious and vigilant approach to managing these treatments. The study's findings emphasize the importance of carefully monitoring patients on ICIs for potential adverse effects and implementing early intervention strategies to prevent severe complications. This is like navigating a vast desert, where unanticipated challenges can arise, requiring vigilance and the ability to quickly adapt to changing circumstances.
Balancing Benefits and Risks: A Crucial Consideration
This research underscores the importance of carefully weighing the benefits and risks of ICI therapy, acknowledging that while these treatments offer promising potential for cancer management, they can also carry significant risks. This study serves as a reminder that the desert of cancer treatment is often treacherous and requires careful navigation, guided by a strong understanding of both the benefits and potential complications of each treatment approach.
Dr. Camel's Conclusion
This case report highlights the potential for severe and even fatal complications associated with immune checkpoint inhibitor therapy, emphasizing the importance of careful monitoring and early intervention to prevent adverse events.
Date :
- Date Completed 2023-01-04
- Date Revised 2023-01-11
Further Info :
Related Literature
English
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