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Frontline combination of ponatinib and hyper-CVAD in Philadelphia chromosome-positive acute lymphoblastic leukemia: 80-months follow-up results.
Author: DiNardoCourtney D, Garcia-ManeroGuillermo, GarrisRebecca, HaddadFadi G, HuangXuelin, JabbourElias, JainNitin, JorgensenJeffrey, KantarjianHagop, KebriaeiPartow, KhouriIssa, KwariMonica, LoghaviSanam, O'BrienSusan, PemmarajuNaveen, RavandiFarhad, SasakiKoji, ShortNicholas J, WierdaWilliam
Original Abstract of the Article :
The combination of ponatinib, a third-generation BCR::ABL1 tyrosine kinase inhibitor, with hyper-CVAD chemotherapy resulted in high rates of complete molecular remissions and survival, without the need for stem cell transplantation (SCT) in most patients with Philadelphia chromosome(Ph)-positive acu...See full text at original site
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引用元：
https://doi.org/10.1002/ajh.26816
データ提供：米国国立医学図書館（NLM）
Ponatinib and Hyper-CVAD: A New Standard of Care for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL), like a raging desert fire, can be a devastating disease. This study explores the effectiveness of a novel combination therapy, ponatinib and hyper-CVAD, for treating Philadelphia chromosome-positive ALL. The researchers, like firefighters battling a blaze, sought to find a more effective and sustainable approach to managing this aggressive cancer.
Ponatinib and Hyper-CVAD: A Powerful Alliance for Fighting ALL
The study found that the combination of ponatinib, a third-generation tyrosine kinase inhibitor, and hyper-CVAD chemotherapy led to high rates of complete molecular remission and survival in patients with Philadelphia chromosome-positive ALL. These promising results, like a cool breeze extinguishing a wildfire, offer hope for a more effective and less invasive treatment approach.
A New Oasis in the Desert of Leukemia Treatment
This study highlights the importance of continued research and development in the field of leukemia treatment. The researchers' findings, like a hidden oasis providing respite and renewal, offer a glimmer of hope for patients with Philadelphia chromosome-positive ALL. The study underscores the need for personalized treatment plans that consider the individual patient's needs and response to therapy.
Dr.Camel's Conclusion
This study presents a compelling case for the use of ponatinib and hyper-CVAD as a novel and effective treatment strategy for Philadelphia chromosome-positive ALL. The researchers' findings, like a beacon of hope illuminating a path through a dark desert, offer a promising new approach to managing this aggressive form of leukemia. This study is a testament to the relentless pursuit of innovation and the dedication to finding better treatments for patients battling cancer.
Date :
- Date Completed 2023-02-16
- Date Revised 2023-03-03
Further Info :
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