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Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model.

Author: BendahanDavid, GiannesiniBenoit, Le FurYann, MessonnierLaurent A, MichelConstance P, VilmenChristophe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hydroxyurea (HU) treatment in sickle cell disease (SCD) mice showed a beneficial effect on muscle function, potentially due to its impact on oxygen delivery. While HU did not alter muscle energetics, it significantly increased specific force production, suggesting a potential role in maintaining muscle function during aging in SCD.
Paper Details　
Original Abstract of the Article :
Hydroxyurea (HU) is commonly used as a treatment for patients with sickle cell disease (SCD) to enhance fetal hemoglobin production. This increased production is expected to reduce anemia (which depresses oxygen transport) and abnormal Hb content alleviating clinical symptoms such as vaso-occlusive ...See full text at original site
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引用元：
https://doi.org/10.1152/japplphysiol.00333.2022

データ提供：米国国立医学図書館（NLM）

Hydroxyurea's Impact on Skeletal Muscle Energetics

This study explores the effects of hydroxyurea (HU), a commonly used treatment for sickle cell disease (SCD), on skeletal muscle energetics and function. The researchers investigated the impact of HU on muscle energy production and force generation in a mouse model of SCD. The findings suggest that HU treatment may have a beneficial effect on muscle function, potentially improving force production.

Hydroxyurea - Benefits for Muscle Function

The study found that HU treatment in SCD mice led to a significant increase in specific force production compared to untreated mice. This finding indicates that HU may play a role in preserving muscle function in individuals with SCD.

Sickle Cell Disease and Muscle Health

The study highlights the potential benefits of HU treatment for muscle health in individuals with SCD. However, further research is needed to understand the long-term effects of HU on muscle function and to explore potential strategies for optimizing its use to maximize benefits.

Dr.Camel's Conclusion

Think of a camel caravan struggling to cross a vast desert landscape. Sickle cell disease is like a harsh desert environment that can weaken and hinder the caravan's progress. Hydroxyurea is like a refreshing oasis that provides support and revitalizes the caravan, helping it continue its journey with renewed strength. This research suggests that HU may offer a valuable tool for improving muscle function in individuals with SCD, potentially leading to better quality of life.
Date :
  1. Date Completed 2023-02-08
  2. Date Revised 2023-02-14
Further Info :

Pubmed ID

36603048

DOI: Digital Object Identifier

10.1152/japplphysiol.00333.2022

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Article Analysis
・Effects of hydroxyurea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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