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Obeticholic acid and 5β-cholanic acid 3 exhibit anti-tumor effects on liver cancer through CXCL16/CXCR6 pathway.

Author: GouHaoxian, HeKai, LiuLinxin, LiuShenglu, LuoMing, QinShu, YangXiaoli

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Liver sinusoidal endothelial cells (LSEC) secrete CXCL16, which increases the accumulation of CXCR6+ natural killer T (NKT) cells in the liver, potentially leading to potent antitumor effects. This study confirms the role of the CXCL16/CXCR6 axis in HCC and suggests that combining obeticholic acid with 5β-cholanic acid 3 might be a promising immunotherapy strategy for HCC.
Paper Details　
Original Abstract of the Article :
Hepatocellular carcinoma (HCC) is the most common type of liver malignancy with a high incidence and mortality rate. Previous <i>in vitro</i> and <i>in vivo</i> studies have confirmed that liver sinusoidal endothelial cells (LSEC) secrete CXCL16, which acts as a messenger to increase the hepatic acc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807878/

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid and 5β-cholanic Acid 3: A New Hope for Liver Cancer Treatment

Hepatocellular carcinoma (HCC) is a formidable foe, with a high incidence and mortality rate. This study explores a new therapeutic approach using a combination of obeticholic acid and 5β-cholanic acid 3 to combat HCC. The authors delve into the intricate workings of the CXCL16/CXCR6 pathway, highlighting its role in activating natural killer T (NKT) cells, which are essential for fighting cancer. They demonstrate that this combination therapy effectively suppresses tumor growth in an orthotopic liver tumor model. The study is like a journey across the vast desert of liver cancer, searching for a hidden oasis of effective treatment.

CXCL16/CXCR6 Pathway: A Gateway to Liver Cancer Treatment

The research identifies the CXCL16/CXCR6 pathway as a promising target for HCC immunotherapy. This pathway serves as a bridge, connecting the immune system to the tumor, allowing NKT cells to mount a potent anti-tumor attack. The study highlights the potential of targeting this pathway to enhance the efficacy of HCC treatment. It’s like finding a hidden gateway in the desert, revealing a path to a more effective and targeted approach to treating liver cancer.

Navigating the Sands of Liver Cancer: A New Perspective

This research offers a new perspective on liver cancer treatment, emphasizing the importance of harnessing the body’s own immune system to fight the disease. It’s like discovering a new wellspring of hope in the vast desert of liver cancer research, offering a promising avenue for future treatment strategies. This study highlights the potential of combination therapies to enhance anti-tumor effects, paving the way for more effective treatment options for HCC.

Dr.Camel's Conclusion

This research unveils the potential of obeticholic acid and 5β-cholanic acid 3 in combination therapy for hepatocellular carcinoma (HCC). It’s like discovering a hidden oasis in the vast desert of liver cancer research, offering a new path towards more effective treatment options. The study’s findings are promising and underscore the importance of exploring new therapeutic strategies to combat this challenging disease.

Date :
  1. Date Completed 2023-01-09
  2. Date Revised 2023-01-19
Further Info :

Pubmed ID

36605219

DOI: Digital Object Identifier

PMC9807878

Related Literature

Article Analysis
・Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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