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HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2).

Author: AlShabeebMohammad, AlomarFadhel A, BidaseeKeshore R, BidaseeSean R, EdagwaBenson J, PalermoNicholas Y, PayneJason J, SchroderEvan, TianChengju, VennZachary L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

HIV-Tat and antiretroviral drugs, including atazanavir, efavirenz, and ritonavir, can bind to and modulate the activity of type 2 ryanodine receptor (RyR2), a key regulator of cardiac function. This modulation might contribute to the increased risk of sudden cardiac death (SCD) in people living with HIV infection, especially those with inadequate viral suppression.
Paper Details　
Original Abstract of the Article :
The incidence of sudden cardiac death (SCD) in people living with HIV infection (PLWH), especially those with inadequate viral suppression, is high and the reasons for this remain incompletely characterized. The timely opening and closing of type 2 ryanodine receptor (RyR2) is critical for ensuring ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820108/

データ提供：米国国立医学図書館（NLM）

HIV-Tat: A Double Whammy for the Heart

This study explores the intricate world of HIV infection and its impact on the heart, a complex terrain rife with unexpected challenges. The researchers delve into the role of HIV-Tat, a protein produced by the virus, and its ability to exacerbate the effects of certain antiretroviral drugs on the cardiac ryanodine receptor (RyR2), a vital component of heart muscle function. This research is like a journey through a hidden oasis, uncovering previously unknown interactions between HIV, antiretroviral drugs, and heart health.

Unveiling the Hidden Risks

The study found that HIV-Tat can potentiate the effects of atazanavir, efavirenz, and ritonavir, commonly used antiretroviral drugs, on the RyR2. This finding highlights the potential for these drugs to disrupt normal heart function, potentially increasing the risk of arrhythmias and sudden cardiac death in people living with HIV. This research, like a detective solving a complex case, is uncovering important insights into the potential risks associated with HIV treatment.

Living with HIV: Understanding the Risks

This study emphasizes the importance of careful monitoring and management of heart health in individuals living with HIV. It is a reminder that even seemingly beneficial treatments can have unexpected consequences. As we traverse the desert of HIV research, it is crucial to remain vigilant and seek to minimize the risks associated with both the virus and its treatments.

Dr.Camel's Conclusion

This study provides valuable insights into the complex interactions between HIV-Tat, antiretroviral drugs, and the heart. It highlights the need for ongoing research to understand the potential risks of these medications and to develop safer and more effective treatment strategies for people living with HIV. Just as a camel navigates a desert landscape, we must navigate the complex world of HIV research with caution and perseverance.

Date :
  1. Date Completed 2023-01-10
  2. Date Revised 2023-05-17
Further Info :

Pubmed ID

36613717

DOI: Digital Object Identifier

PMC9820108

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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