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Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4.

Author: GaoArwen W, HoutkooperRiekelt H, JanssensGeorges E, JongejanAldo, KambleRashmi, McIntyreRebecca L, MolenaarsMarte, PossematoRichard, SchomakersBauke V, van KuilenburgAndré B P, van WeeghelMichel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study explores the geroprotective effects of zidovudine, an anti-retroviral nucleoside reverse transcriptase inhibitor, in C. elegans. The findings suggest that zidovudine extends lifespan and health span by modifying pyrimidine metabolism and regulating proteostasis, ultimately activating transcription factor 4 (ATF-4).
Paper Details　
Original Abstract of the Article :
The human population is aging, and the need for interventions to slow progression of age-related diseases (geroprotective interventions) is growing. Repurposing compounds already used clinically, usually at modified doses, allows rapid implementation of geroprotective pharmaceuticals. Here we find t...See full text at original site
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引用元：
https://doi.org/10.1016/j.celrep.2022.111928

データ提供：米国国立医学図書館（NLM）

Zidovudine: A New Perspective on Aging

[Aging] is a natural process that affects all living organisms. While scientists continue to explore [ways to slow down aging], this study investigates the potential of [zidovudine], a drug commonly used for [HIV treatment], to [extend lifespan and improve healthspan] in [C. elegans, a model organism]. The authors used [a combination of genetic, biochemical, and lifespan analysis] to explore the [mechanisms behind zidovudine’s effects on aging]. The study reveals that [zidovudine alters pyrimidine metabolism and reduces translation, ultimately extending lifespan and improving healthspan]. This discovery suggests that [zidovudine] may have a potential role in [future anti-aging therapies].

Zidovudine: A New Twist on an Old Drug

The study found that [zidovudine], a drug typically used for [HIV treatment], can [increase lifespan and improve health] in [C. elegans]. It’s like a camel finding a hidden oasis in the desert – a surprising discovery that could lead to [new applications for an existing drug].

A Potential Anti-Aging Elixir?

This study offers a fascinating new perspective on [aging]. It suggests that [zidovudine] may offer a way to [extend lifespan and improve health]. Remember, just as a camel can adapt to the harsh conditions of the desert, researchers are always looking for ways to [adapt our understanding of aging].

Dr.Camel's Conclusion

This study presents exciting evidence for the [potential of zidovudine as a geroprotective agent]. It’s a reminder that [science is constantly evolving], and what we know today may be different tomorrow. The findings suggest that [zidovudine] may offer a new way to [combat the effects of aging].

Date :
  1. Date Completed 2023-02-06
  2. Date Revised 2023-02-06
Further Info :

Pubmed ID

36640360

DOI: Digital Object Identifier

10.1016/j.celrep.2022.111928

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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