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Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila.

Author: CaiHui, HanShuzhen, HeJianzheng, LiShuang, LinXingyao, LiuYongqi, ShiYan, WangXiaoqian, XiuMinghui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study used Drosophila melanogaster to explore the side effects and mechanism of cytarabine (Ara-C), a widely used drug in acute myeloid leukemia (AML). Ara-C supplementation delayed larval development, reduced lifespan, and increased susceptibility to stress response in adult flies. This suggests Drosophila as a potential in vivo model for assessing chemotherapy toxicity and screening for protective drugs.
Paper Details　
Original Abstract of the Article :
Cytarabine (Ara-C) is a widely used drug in acute myeloid leukemia (AML). However, it faces serious challenges in clinical application due to serious side effects such as gastrointestinal disorders and neurologic toxicities. Until now, the mechanism of Ara-C-induced damage is not clear. Here, we use...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopha.2023.114265

データ提供：米国国立医学図書館（NLM）

Exploring Cytarabine's Side Effects: A Drosophila Perspective

This research takes a unique approach to understanding the side effects of cytarabine, a commonly used chemotherapy drug, by using Drosophila melanogaster (fruit flies) as an in vivo model. The study investigates the mechanisms behind cytarabine-induced damage, which is particularly important for understanding how to mitigate adverse effects in patients.

Drosophila: A Tiny Model With Big Insights

The study found that cytarabine supplementation in fruit flies led to a delay in larval development, reduced lifespan, impaired movement, and increased susceptibility to stress. These findings are significant because they demonstrate the potential for cytarabine to affect multiple aspects of development and physiology. It's like studying a small sand dune to understand the dynamics of an entire desert!

Unraveling Cytarabine's Effects on the Gut

The study revealed that cytarabine caused intestinal damage and increased reactive oxygen species (ROS) accumulation in the guts of fruit flies. This highlights the potential impact of cytarabine on the gastrointestinal system, which is a common side effect in patients. This is a crucial area of study as it can pave the way for future therapeutic interventions aimed at mitigating these effects.

Dr.Camel's Conclusion

This study provides valuable insights into the side effects of cytarabine, using fruit flies as a model organism. By understanding the mechanisms behind cytarabine-induced damage, we can develop strategies for mitigating these adverse effects and improving the safety of this important chemotherapy drug. As scientists, we must continue to explore the desert of knowledge, discovering new insights that can lead to better therapies for patients.

Date :
  1. Date Completed 2023-02-07
  2. Date Revised 2023-02-07
Further Info :

Pubmed ID

36652735

DOI: Digital Object Identifier

10.1016/j.biopha.2023.114265

SNS
PICO Info
in preparation
Languages

English

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