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Study on the hepatotoxicity and potential mechanism of gefitinib based on CYP450 in mice and AML12 cells.

Author: BaiMing, LiCaiyin, LiMengyuan, LiYucheng, LiuHui, LuShuaifei, MaSuzhen, SuPan, YinXiaoting, ZhangChangjing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Gefitinib-induced hepatotoxicity may be associated with CYP1A1, CYP2D9, and CYP2D10, suggesting a potential mechanism for the side effect.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Gefitinib is mainly used for the treatment of non-small-cell lung cancer. Hepatotoxicity is one of the main side effects of gefitinib, and seriously affects the treatment process of the disease. However, the hepatotoxicity mechanism of gefitinib remains unclear. METHODS: The hepatotoxic...See full text at original site
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引用元：
https://doi.org/10.1093/jpp/rgac091

データ提供：米国国立医学図書館（NLM）

Gefitinib's Side Effects: Unraveling the Mechanism of Hepatotoxicity

Gefitinib, a drug commonly used to treat non-small-cell lung cancer, is known to have side effects, one of which is hepatotoxicity. This study aimed to investigate the mechanism behind this adverse effect. The researchers employed a multifaceted approach, examining the impact of gefitinib on the liver in both mice and human liver cells. They meticulously analyzed the drug's influence on specific enzymes involved in liver function, revealing a potential link between gefitinib and the development of hepatotoxicity.

CYP450 Enzymes: The Key to Understanding Gefitinib's Toxicity

The study identified a significant correlation between gefitinib-induced hepatotoxicity and the activity of specific CYP450 enzymes. These enzymes play a crucial role in the metabolism of drugs, including gefitinib. The findings suggest that gefitinib's impact on these enzymes could contribute to its hepatotoxic effects. This understanding is crucial for developing strategies to mitigate these side effects and ensure the safe and effective use of gefitinib in cancer treatment.

Navigating the Desert of Drug Side Effects

Imagine a desert landscape, filled with hidden dangers and unexpected challenges. Drug side effects are like those hidden dangers, often unforeseen and potentially harmful. This study provides valuable insights into the complex relationship between gefitinib and the liver. Understanding this connection can help us navigate the desert of potential side effects, making informed decisions about medication and ensuring the safety and well-being of patients.

Dr.Camel's Conclusion

This research takes us on a journey through the intricate mechanisms of drug metabolism and its impact on the liver. The findings offer a deeper understanding of gefitinib's hepatotoxicity, paving the way for smarter drug development and safer treatment strategies for patients with cancer.
Date :
  1. Date Completed 2023-03-14
  2. Date Revised 2023-03-14
Further Info :

Pubmed ID

36656101

DOI: Digital Object Identifier

10.1093/jpp/rgac091

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Article Analysis
・Side Effects of gefitinib
SNS
PICO Info
in preparation
Languages

English

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