Paper Details

  1. Home
  2. Paper Details

Antimicrobial phyto-photodynamic activity inducing by polyphenol-supported Methylene Blue co-loaded into multifunctional bilosomes: Advanced hybrid nanoplatform in the skin infections treatment?

Author: BazylińskaUrszula, MaliszewskaIrena, WaglewskaEwelina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explores the use of nanoengineered self-assembling bilosomes for delivering curcumin and methylene blue for phyto-photodynamic antimicrobial therapy against Staphylococcus aureus and Candida albicans. Double-loaded bilosomes with curcumin and methylene blue exhibited higher reactive oxygen species generation and enhanced photoactivity, leading to effective microbial cell reduction.
Paper Details　
Original Abstract of the Article :
Widespread skin infections caused primarily by bacteria and yeast, pose a growing threat to healthcare systems. Phyto-photodynamic antimicrobial therapy is a promising treatment strategy with a few mild side effects for both superficial and deeper skin infections. The combination of natural plant pr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.jphotobiol.2023.112650

データ提供：米国国立医学図書館（NLM）

Skin Infections: Harnessing the Power of Light and Nature

Skin infections are a common problem, and new approaches to treatment are constantly being explored. This study investigates the potential of a novel antimicrobial phyto-photodynamic therapy, combining the power of light and natural plant products, for treating skin infections. The researchers developed a nanoengineered platform to deliver both a photosensitizer (Methylene Blue) and a phytochemical compound (curcumin) to target bacteria and yeast.

A Synergistic Approach: Light and Nature Combine

The study found that the combination of Methylene Blue and curcumin, delivered through a bioinspired bilosome nanoparticle system, significantly enhanced the generation of reactive oxygen species, which can effectively kill bacteria and yeast. This synergistic approach resulted in a greater reduction in microbial cell numbers compared to using Methylene Blue alone. The researchers also demonstrated that the bilosomes prevented rapid photobleaching of Methylene Blue, further enhancing its photoactivity.

A Promising Future: Innovations in Skin Infection Treatment

This study presents a promising new strategy for treating skin infections, combining the power of light and nature in a synergistic way. The researchers' innovative approach offers a potential alternative to traditional antibiotics, which are increasingly facing resistance. This research could pave the way for a new era of effective and safe skin infection treatments.

Dr.Camel's Conclusion

This study delves into the exciting field of antimicrobial phyto-photodynamic therapy, demonstrating the potential of a novel approach to treating skin infections. By combining the power of light and natural compounds, this approach offers a promising alternative to traditional antibiotics, addressing the growing problem of antibiotic resistance. This research is a significant step forward in the quest for more effective and safe treatments for skin infections.

Date :
  1. Date Completed 2023-03-01
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

36701884

DOI: Digital Object Identifier

10.1016/j.jphotobiol.2023.112650

Related Literature

Article Analysis
・Effective treatment of skin infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.