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Serum concentrations of salicylate and naproxen during concurrent therapy in patients with rheumatoid arthritis.

Author: BlockaK, CassellS, DromgooleS, FurstD E, HarrisE R, HirschbergJ M, JosephsonN, PaulusH E, SarkissianE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Salicylate decreased serum naproxen concentration and increased serum naproxen clearance, while naproxen had minimal effect on serum salicylate concentrations.
Paper Details　
Original Abstract of the Article :
The kinetic interaction between salicylate and naproxen was investigated in 25 rheumatoid arthritis patients. Kinetic interactions were tested in serum after patients had been on each drug regimen for 1 month. Salicylate decreased serum naproxen concentration from 89.5 mg/liter to 65.9 mg/liter (P l...See full text at original site
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引用元：
https://doi.org/10.1002/art.1780301011

データ提供：米国国立医学図書館（NLM）

The Kinetic Interaction Between Salicylate and Naproxen

This study is like a scientific expedition, exploring the complex interplay of two medications - salicylate and naproxen - commonly used to treat rheumatoid arthritis. The researchers, like intrepid explorers, investigated how these medications interact in the body and their impact on each other's effectiveness.

Their findings, like a well-documented journal of their journey, revealed that salicylate decreases serum naproxen concentrations and increases its clearance, while naproxen has minimal effect on salicylate levels. This study provides valuable insights into the pharmacokinetic interactions between these medications, highlighting the importance of careful monitoring and dosage adjustments.

This study is a reminder that even in the desert of medication interactions, there are hidden oases of knowledge waiting to be discovered. It underscores the importance of careful medication management, particularly when patients are taking multiple medications simultaneously.

Understanding Drug Interactions

The study emphasizes the importance of understanding drug interactions, particularly when patients are taking multiple medications. This knowledge can help healthcare providers optimize treatment regimens and minimize potential side effects.

Safe and Effective Medication Management

Patients should always consult with their healthcare providers about any medications they are taking, including over-the-counter medications and supplements. This will help ensure safe and effective medication management and minimize the risk of adverse interactions.

Dr.Camel's Conclusion

This research is like a map guiding us through the complex terrain of drug interactions. Understanding these interactions is essential for safe and effective medication management, and this study provides valuable insights into the complex relationship between salicylate and naproxen.

Date :
  1. Date Completed 1987-12-11
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

3675660

DOI: Digital Object Identifier

10.1002/art.1780301011

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Languages

English

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