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The Effects of Treatment in Psychotic Disorders-Changes in BDNF Levels and Clinical Outcomes: Systematic Review.

Author: MosiołekAnna, MosiołekJadwiga

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Brain-derived neurotrophic factor (BDNF) is a potential biomarker for psychotic disorders, as decreased levels can impair neuronal signaling and contribute to symptoms like working memory impairment. This review analyzes the influence of antipsychotic and non-pharmacological treatments on BDNF levels in patients with psychotic disorders. While some studies show an increase in BDNF levels with antipsychotic treatment, further research is needed to establish a clear correlation with clinical outcomes.
Paper Details　
Original Abstract of the Article :
Psychotic disorders are associated with significant impairment in functioning, and their treatment remains a great therapeutic challenge. Patients are at a higher risk of suicide and premature mortality. Biomarkers, such as brain-derived neurotrophic factor (BDNF), play a vital role in neurotransmis...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915041/

データ提供：米国国立医学図書館（NLM）

Understanding the Role of BDNF in Psychotic Disorders

This research explores the complex interplay between brain-derived neurotrophic factor (BDNF) levels and the treatment of psychotic disorders. The authors, like skilled cartographers mapping the intricate landscape of the brain, delve into the role of BDNF in neurotransmission and neurodevelopment. Their findings highlight the importance of BDNF in understanding the underlying mechanisms of psychotic disorders and their treatment response. BDNF, like a vital oasis in a vast desert, plays a critical role in supporting neuronal survival, growth, and function.

The Impact of Treatment on BDNF Levels

This research underscores the importance of considering BDNF levels when treating psychotic disorders. The authors found that different treatments, including both pharmacological and non-pharmacological approaches, can have varying effects on BDNF levels. While some treatments, such as antipsychotic medications, were associated with increased BDNF levels, other treatments showed mixed results. The study suggests that further research is needed to fully understand the complex relationship between treatment and BDNF levels in psychotic disorders.

The Need for Personalized Treatment Approaches

This research emphasizes the need for personalized treatment approaches for individuals with psychotic disorders. Each individual, like a unique sand dune shaped by the winds of their genetic makeup and life experiences, may respond differently to treatment. The authors highlight the importance of considering individual factors such as genetics and the individual's unique circumstances in developing personalized treatment plans.

Dr. Camel's Conclusion

This research is a valuable contribution to our understanding of the role of BDNF in psychotic disorders. It provides a framework for future research to explore the potential of targeting BDNF in the development of more effective and personalized treatment approaches.
Date :
  1. Date Completed 2023-02-16
  2. Date Revised 2023-03-17
Further Info :

Pubmed ID

36767478

DOI: Digital Object Identifier

PMC9915041

Related Literature

Article Analysis
・Effective treatment of psychotic disorders
SNS
PICO Info
in preparation
Languages

English

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