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Ketamine as advanced second-line treatment in benzodiazepine-refractory convulsive status epilepticus in children.

Author: BriscaGiacomo, BurattiSilvia, GiacheriEmanuele, MancardiMaria Margherita, MoscatelliAndrea, NobiliLino, PalmieriAntonella, RivaAntonella, StrianoPasquale, TibaldiJessica

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, shows potential as a second-line treatment for status epilepticus (SE) refractory to benzodiazepines, offering antiepileptic, neuroprotective, and synergistic effects with other antiseizure medications.
Paper Details　
Original Abstract of the Article :
Status epilepticus (SE) is one of the most common neurological emergencies in children. To date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines. The main objectives of treatment protocols are to expedite therapeutic decisions and to use fast- and short-acting ...See full text at original site
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引用元：
https://doi.org/10.1111/epi.17550

データ提供：米国国立医学図書館（NLM）

Ketamine: A Second-Line Defender Against Seizures

Greetings, fellow knowledge seekers! Dr. Camel here, and I'm always eager to learn about new ways to tackle the challenges of medicine. Status epilepticus (SE), a condition where seizures continue for an extended period, is a challenging beast. This research delves into the use of ketamine as a possible treatment for SE, especially in children who don't respond to traditional medications.

The researchers compared ketamine to other commonly used medications, like valproate and phenytoin. Imagine a desert caravan facing a sudden sandstorm. Ketamine, in this case, acts like a sturdy camel, able to carry the caravan through the storm when other camels struggle.

A New Camel for the Caravan

Ketamine is a powerful drug that works by blocking certain receptors in the brain. The study suggests that ketamine may be a good option for children with SE that doesn't respond to other treatments. It's like having a backup camel ready to take over when the others get tired.

Navigating the Stormy Brain

While ketamine may be a promising new tool, its use requires careful consideration. It's not a magic bullet, and we must remember that each child's brain is unique, like a desert with its own specific set of challenges.

Dr.Camel's Conclusion

Ketamine holds a lot of promise for treating refractory SE in children. It's like a desert oasis appearing amidst the harsh storm. However, further research is needed to fully understand its benefits and risks.

Date :
  1. Date Completed 2023-04-14
  2. Date Revised 2023-04-17
Further Info :

Pubmed ID

36792542

DOI: Digital Object Identifier

10.1111/epi.17550

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・Side Effects of phenytoin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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