Toxicity of Asciminib in Real Clinical Practice: Analysis of Side Effects and Cross-Toxicity with Tyrosine Kinase Inhibitors.

Author: Alonso-DomínguezJuan Manuel, Alvarez-LarránAlberto, AngonaAnna, Anguita AranceMaría Magdalena, BoqueConcepción, Carrascosa MastellPatricia, CerveroCarlos, ColoradoMercedes, CortésMontse, CuevasBeatriz, De Las HerasNatalia, Felipe CasadoLuis, FernándezMaría José, García-GutiérrezValentín, GiraldoPilar, GómezValle, Hernández-BoludaJuan Carlos, Jiménez-VelascoAntonio, LakhwaniSunil, Lis ChulviMaría José, LunaAlejandro, López MarínJavier, Mora CasteráElvira, Moreno VegaMelania, Paz CollAntonio, PrendesSantiago Osorio, Pérez EncinasManuel, Pérez LópezRaúl, Pérez-LamasLucía, RamilaElena, RosellAna, Ruiz NuñoConcepción, Salamanca CuencaAraceli, SantaliestraMarta, Segura DíazAdrián, Sierra PachoMagdalena, Vera GoñiJuan Antonio, Villalón BlancoLucía, Vélez TenzaPatricia, XicoyBlanca, de PazRaquel

Paper Details 
Original Abstract of the Article :
(1) Background: Despite the prognostic improvements achieved with tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), a minority of patients still fail TKIs. The recent introduction of asciminib may be a promising option in intolerant patients, as it is a first-in-class inhibitor wi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954054/

データ提供:米国国立医学図書館(NLM)

Asciminib: A New Hope in Chronic Myeloid Leukemia Treatment

Chronic myeloid leukemia (CML) is a complex and challenging disease, like a sandstorm that can be difficult to navigate. This study explores the use of asciminib, a new drug that is being investigated as a potential treatment for patients who have not responded well to traditional tyrosine kinase inhibitors (TKIs). It’s like searching for a new route through the desert, one that might offer a more effective way to overcome the obstacles.

A Promising New Treatment Option

The study found that asciminib had a good safety profile and was well-tolerated by patients. It also showed promise in treating CML in patients who had not responded well to other TKIs. It’s like finding a new oasis in the desert, one that offers a haven from the challenges of the journey.

Potential Cross-Toxicity

The study did note that there was a risk of cross-toxicity with other TKIs, meaning that some side effects may be similar to those seen with other TKIs. This is like finding a beautiful path through the desert, but realizing that it may lead to a different obstacle that requires a different solution.

Dr.Camel's Conclusion

This research offers hope for patients with CML who have not responded well to other treatment options. Asciminib is a promising new drug, but further studies are needed to fully understand its long-term effects. It’s a reminder that the search for new treatments is an ongoing journey, much like a camel traversing the vast and unpredictable desert, always searching for a better path.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-02-27
Further Info :

Pubmed ID

36831388

DOI: Digital Object Identifier

PMC9954054

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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