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Impact of Innovative Treatment Using Biological Drugs for the Modulation of Diffuse Cutaneous Systemic Sclerosis: A Systematic Review.

Author: Fernández-LázaroDiego, GarrosaEvelina, Gutiérrez-AbejónEduardo, Iglesias-LázaroMaría, Jerves DonosoDavid, Jorge-FinniganConrado, Rodríguez-GarcíaSaray

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This systematic review summarizes the current evidence on the effects of biological drugs on pulmonary function, skin disease, and health status in patients with diffuse cutaneous systemic sclerosis (dcSSc). While biological drugs like tocilizumab, belimumab, riociguat, abatacept, and romilkimab showed trends towards improvement, there was no significant benefit on health status compared to control groups. These drugs may offer a new therapeutic strategy for dcSSc, potentially promoting anti-fibrotic activity.
Paper Details　
Original Abstract of the Article :
Scleroderma or systemic sclerosis (SSc) is an autoimmune disease affecting the connective tissue, characterized by fibrosis of the skin and internal organs. There is currently no curative treatment available, so therapeutic action is aimed at a symptomatic treatment of the affected organs. The devel...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967997/

データ提供：米国国立医学図書館（NLM）

A New Frontier in Scleroderma Treatment: Exploring the Potential of Biological Drugs

This research delves into the potential of [biological drugs] to modulate the progression and symptoms of [diffuse cutaneous systemic sclerosis (dcSSc)], a complex autoimmune disorder. It's like seeking new solutions in the vast desert of scleroderma research, looking for ways to combat the fibrosis and inflammation that characterize this condition.

A Promising Oasis: Biological Drugs for dcSSc

The research suggests that certain [biological drugs] could potentially offer new therapeutic options for patients with [dcSSc], providing a glimmer of hope in the desert of this disease. It's like discovering a new spring of healing potential in the vast desert of scleroderma research.

Navigating the Desert of Scleroderma: Seeking Innovative Treatments

This research highlights the need for continued exploration of novel therapies for [dcSSc]. It's like seeking new paths through the desert of this disease, striving for more effective and less toxic treatments that can improve the lives of patients.

Dr.Camel's Conclusion

This research is a testament to the ongoing efforts to find new ways to treat [dcSSc], offering hope for improved outcomes and a better quality of life for those living with this challenging condition. It's a reminder that even in the desert of illness, there can be oases of progress and innovation.

Date :
  1. Date Completed 2023-02-28
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

36837449

DOI: Digital Object Identifier

PMC9967997

Related Literature

Article Analysis
・Effects of riociguat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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