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Pharmacological Treatment of Tremor in Parkinson's Disease Revisited.

Author: HallettMark, KatzenschlagerRegina, PirkerWalter, PoeweWerner

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levodopa is the most effective drug for Parkinson's disease tremor, but other medications, such as dopamine agonists and anticholinergics, can be used as well. However, anticholinergics have limited benefits due to their side effects. For patients with drug-refractory tremor, deep brain stimulation and focused ultrasound are potential treatments. Surgery can also be highly effective in selected patients without motor fluctuations.
Paper Details　
Original Abstract of the Article :
The pathophysiology of Parkinson's disease (PD) tremor remains incompletely understood and there is a lack of clinical trials specifically addressing its pharmacological treatment. Levodopa is the most efficacious drug for most patients and should be used as primary approach to control troublesome t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041452/

データ提供：米国国立医学図書館（NLM）

Tremor in Parkinson's Disease: A Shifting Desert of Treatment Options

Parkinson's disease (PD), a neurodegenerative disorder, can manifest with a variety of symptoms, including tremor. This review comprehensively evaluates the pharmacological treatment of tremor in PD, examining the effectiveness of different medications and exploring alternative approaches. The authors highlight levodopa as the mainstay treatment for PD tremor, but discuss the limitations of dopamine agonists and anticholinergics in tremor control. They also explore the role of propranolol, clozapine, and other medications in treating tremor. The review emphasizes the importance of individualized treatment approaches and discusses the potential benefits of deep brain stimulation and focused ultrasound for drug-refractory tremor. This review offers a comprehensive overview of the current landscape of pharmacological treatment options for PD tremor.

A Dynamic Landscape: Managing Tremor in Parkinson's Disease

The review, like a guide through a constantly shifting desert landscape, reveals the dynamic nature of PD tremor treatment. The authors provide a detailed overview of the current understanding of tremor pathophysiology and highlight the effectiveness of different medications and surgical approaches. This review underscores the importance of personalized treatment strategies and the ongoing pursuit of new therapies to improve the lives of patients with PD.

Navigating the Sands of Parkinson's Disease: A Multifaceted Approach

If you are living with PD, it is essential to work closely with your healthcare team to develop a personalized treatment plan that effectively manages your symptoms, including tremor. The journey through PD treatment is best navigated with a knowledgeable guide and a commitment to continuous improvement. Remember, the desert of PD research is vast, but with each new discovery, we move closer to a brighter future for those living with this challenging disease.

Dr.Camel's Conclusion

This review comprehensively evaluates the pharmacological treatment of tremor in Parkinson's disease, offering a detailed overview of current approaches and highlighting the importance of individualized treatment strategies. The ongoing pursuit of new therapies, including deep brain stimulation and focused ultrasound, holds promise for improving the lives of patients living with PD. Remember, the journey through the desert of PD research is best navigated with a spirit of hope and a commitment to finding new solutions.

Date :
  1. Date Completed 2023-03-21
  2. Date Revised 2023-04-05
Further Info :

Pubmed ID

36847017

DOI: Digital Object Identifier

PMC10041452

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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