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Elabela-apelin-12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1-P2X7 signaling pathway.

Author: CaoJiangang, ChenLinxi, ChenZhe, HeLu, HuHaoliang, HuangShifang, HuangZhen, JiangJinyong, LiLanfang, LiYao, LiuMeiqing, LuoXuling, WangLingzhi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Elabela and apelin, peptides that activate the APJ receptor, were found to induce platelet aggregation and thrombosis by activating the PANX1-P2X7 signaling pathway. Spironolactone, a PANX1 inhibitor, effectively alleviated these effects. Cobicistat and Schisandrin A, drugs that block the APJ receptor, also prevented elabela- and apelin-induced thrombosis. These findings suggest potential new therapies for thrombosis by targeting the elabela-apelin/APJ axis.
Paper Details　
Original Abstract of the Article :
The elabela-apelin/angiotensin domain type 1 receptor-associated protein (APJ) system is an important regulator in certain thrombosis-related diseases such as atherosclerosis, myocardial infarction, and cerebral infarction. Our previous reports have revealed that apelin exacerbates atherosclerotic l...See full text at original site
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引用元：
https://doi.org/10.1002/jcb.30392

データ提供：米国国立医学図書館（NLM）

Elabela-apelin-12, 17, 36/APJ System: A Camel's Journey Through Thrombosis

This research delves into the intricate desert of [thrombosis], a condition that can lead to serious health complications. The study explores the role of the [elabela-apelin/APJ system] in [promoting platelet aggregation and thrombosis]. The researchers investigated the effects of [elabela and other apelin isoforms] on [platelet aggregation and thrombosis] in vitro and in vivo. Their findings revealed that [elabela and apelin isoforms activate the PANX1-P2X7 signaling pathway], leading to [increased platelet aggregation and thrombosis]. Furthermore, they identified [two potential antithrombotic drugs] that [target APJ receptors] and showed that [these drugs effectively inhibited elabela- and apelin-induced platelet aggregation and thrombosis].

The Camel's Insights: What Does This Mean?

The study highlights the crucial role of the [elabela-apelin/APJ system] in regulating [platelet aggregation and thrombosis]. The researchers' detailed investigation, like a camel meticulously navigating a desert of intricate pathways, provides valuable insights for developing new strategies to prevent and treat thrombosis.

The Camel's Health Tips

Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking, can help reduce the risk of thrombosis. If you have any concerns about your risk of thrombosis, it's essential to consult a healthcare professional. Remember, a wise camel always seeks expert advice to navigate the desert of heart health.

Dr. Camel's Conclusion

This research, like a camel's journey through a desert of cardiovascular challenges, reveals the intricate mechanisms that govern platelet aggregation and thrombosis. The study's findings provide hope for developing new and more effective therapies to prevent and treat this serious condition. Remember, a wise camel always seeks the most effective interventions to ensure a healthy heart.

Date :
  1. Date Completed 2023-04-20
  2. Date Revised 2023-06-05
Further Info :

Pubmed ID

36855998

DOI: Digital Object Identifier

10.1002/jcb.30392

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