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Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review.

Author: DutraLucas Santana, GoesJulieta Sobreira, MenezesCatarina Ester Gomes, MoraisLécio Aragão Souza, NeryErick Santos, Portela FilhoMarcos Baruch, SantosDébora Lopes Dos, SerpaEvelin Duarte

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tuberous sclerosis (TS) is a genetic disorder that can cause seizures, which are often difficult to control. Everolimus, a medication that has been shown to be effective for other aspects of TS, may also be helpful for treating seizures that don't respond to standard treatment in people with TS.
Paper Details　
Original Abstract of the Article :
Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of re...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169230/

データ提供：米国国立医学図書館（NLM）

Everolimus: A Potential Oasis in the Desert of Refractory Epilepsy

Epilepsy, a neurological condition that disrupts the brain's delicate balance, presents a significant challenge in the [treatment of tuberous sclerosis (TS)]. This study delves into the potential of [everolimus], a drug with proven efficacy in other TS-related conditions, as a treatment for [refractory epilepsy]. The authors conducted a [systematic review] to evaluate the existing evidence, and their findings suggest [everolimus may be a promising therapeutic option for epilepsy in TS patients]. This study could lead to [improved treatment outcomes and quality of life for individuals with TS and refractory epilepsy].

Everolimus: Hope in the Desert for Epilepsy in Tuberous Sclerosis

The study indicates that everolimus may offer [a new avenue for treating refractory epilepsy] in individuals with TS, a condition that often defies conventional therapies. The authors emphasize [the need for further research] to solidify the efficacy and safety of everolimus in this context.

Navigating the Desert: Epilepsy and Tuberous Sclerosis

The research suggests that everolimus may offer [a glimmer of hope for individuals with TS and refractory epilepsy]. The authors emphasize [the importance of personalized medicine] in this setting, as each patient's response to treatment may vary.

Dr. Camel's Conclusion

The desert of refractory epilepsy in tuberous sclerosis can feel vast and unforgiving. This study offers a promising oasis in the form of everolimus, a drug that has shown potential benefits for these patients. However, further research is needed to confirm its effectiveness and safety. As we continue to explore new treatments, we must remember the importance of individualized care and personalized medicine.

Date :
  1. Date Completed 2023-05-11
  2. Date Revised 2023-05-11
Further Info :

Pubmed ID

36863402

DOI: Digital Object Identifier

PMC10169230

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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