CDK4/6 Inhibitors in Advanced HR+/HER2 - Breast Cancer: A Multicenter Real-World Data Analysis.

Author: AbramianAlina Valik, BlohmerJens-Uwe, KiverVerena, Kolberg-LiedtkeCornelia, MaassNicolai, MüllerCarolin, NeebCaroline, RalserDamian Johannes, RambowAnna-Christina, SchützFlorian, SolomayerErich-Franz, WagenpfeilGudrun

Paper Details 
Original Abstract of the Article :
CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy are considered standard-of-care for first-line therapy of patients with hormone receptor positive, HER2 negative, advanced breast cancer (HR+/HER2- ABC). Superiority of combination therapy over endocrine monotherapy has been demonstrated in...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982335/

データ提供:米国国立医学図書館(NLM)

CDK4/6 Inhibitors: A Real-World Look at Advanced Breast Cancer Treatment

The fight against advanced breast cancer is a constant journey, like a trek across a vast desert, seeking new strategies to improve patient outcomes. This study delves into the real-world application of CDK4/6 inhibitors, a class of drugs that target specific proteins involved in cancer cell growth. The researchers explored the use of these inhibitors in combination with endocrine therapy for patients with hormone receptor-positive, HER2-negative advanced breast cancer.

While clinical trials have shown promise for this combination therapy, this real-world study aimed to assess its effectiveness in a broader patient population, reflecting the diverse challenges encountered in routine clinical practice. The study found that CDK4/6 inhibitors were generally well-tolerated and offered significant clinical benefit in this patient group. However, the authors acknowledge the need for further research to optimize the use of these inhibitors and explore potential long-term effects.

The Power of Real-World Data

This research highlights the importance of real-world data in understanding the true impact of new therapies. By studying patients in routine clinical settings, researchers can gain valuable insights into the effectiveness and safety of treatments beyond the controlled environment of clinical trials.

Empowering Breast Cancer Patients

This study offers hope for patients with advanced breast cancer, providing a real-world perspective on the use of CDK4/6 inhibitors. It's essential to discuss treatment options with your healthcare provider, considering your individual needs and medical history.

Dr. Camel's Conclusion

The desert of breast cancer research is constantly evolving, seeking new oases of knowledge and innovation. This study provides a real-world glimpse into the promise of CDK4/6 inhibitors, offering a beacon of hope for patients navigating this challenging journey. It underscores the importance of ongoing research and collaboration to find the most effective treatments for this complex disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-07
Further Info :

Pubmed ID

36876172

DOI: Digital Object Identifier

PMC9982335

SNS
PICO Info
in preparation
Languages

English

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