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LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells.

Author: DengMingyang, LiuSufang, PengHongling, WangZhihua, XiaoHan, XiaoXiang, YuanHuan, ZhangGuangsen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the roles of LINC00461 in multiple myeloma and its effects on ixazomib therapy. Knockdown of LINC00461 or SNRPB2 enhanced ixazomib's cytotoxicity and affected its regulatory effects on cell apoptosis and cell cycle distribution. LINC00461 knockdown reduced the expression of SNRPB2. The findings suggest that LINC00461 may enhance the therapeutic effects of ixazomib against multiple myeloma through regulation of SNRPB2.
Paper Details　
Original Abstract of the Article :
BACKGROUND: LINC00461 has been implicated to be involved in several types of cancer while its roles in multiple myeloma remain unclear. Our study aims to investigate the roles of LINC00461 in multiple myeloma and explore its effects on ixazomib therapy. METHODS: LINC00461 and small nuclear ribonucl...See full text at original site
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引用元：
https://doi.org/10.2174/1568009623666230316152713

データ提供：米国国立医学図書館（NLM）

Combating Multiple Myeloma: A New Approach with LINC00461

The battle against [multiple myeloma] is like navigating a treacherous sandstorm, a relentless force that can be difficult to overcome. This research delves into the potential of targeting [LINC00461], a long non-coding RNA, as a novel therapeutic approach for [multiple myeloma]. The study investigates the effects of [LINC00461] knockdown on the efficacy of [ixazomib], a medication commonly used to treat [multiple myeloma].

LINC00461 Knockdown Enhances Ixazomib's Effect

The study demonstrates that knockdown of [LINC00461] enhances the cytotoxic effects of [ixazomib], potentially leading to improved treatment outcomes for [multiple myeloma] patients. This is like discovering a hidden spring in the desert, a vital source of rejuvenation and strength for those facing a challenging journey.

Understanding the Role of LINC00461 in Myeloma

This research deepens our understanding of the role of [LINC00461] in [multiple myeloma] and opens new avenues for therapeutic development. Just as a skilled explorer maps a new territory, this study paves the way for more targeted and effective treatments for this complex disease.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the battle against [multiple myeloma]. By exploring the potential of [LINC00461] knockdown, scientists are making strides towards more effective treatment strategies. This is a testament to the enduring spirit of discovery and the unwavering commitment to improving patient outcomes in the face of this challenging disease.

Date :
  1. Date Completed 2023-06-19
  2. Date Revised 2023-11-16
Further Info :

Pubmed ID

36927430

DOI: Digital Object Identifier

10.2174/1568009623666230316152713

Related Literature

Article Analysis
・Effects of ixazomib
SNS
PICO Info
in preparation
Languages

English

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