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Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.

Author: ChaixAmandine, DrummondMicah J, FerraraPatrick J, FixDennis K, FunaiKatsuhiko, LangMarisa J, PetrocelliJonathan J, YeeElena M, de HartNaomi M M P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the mechanisms by which metformin + leucine (MET+LEU) protects against muscle atrophy. MET+LEU treatment prevented myotube atrophy in vitro and in aged mouse myofibers. The treatment also reversed cellular senescence and improved proteostasis, suggesting a cell-autonomous effect on skeletal muscle. These findings suggest that MET+LEU could potentially be used to prevent muscle atrophy in aging populations.
Paper Details　
Original Abstract of the Article :
Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, we found that a metformin + leucine (MET+LEU) ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085594/

データ提供：米国国立医学図書館（NLM）

Metformin and Leucine: Combating Muscle Atrophy and Cellular Senescence

This research explores the potential of a combination of metformin and leucine (MET+LEU) in preventing muscle atrophy and cellular senescence, processes that are associated with aging and contribute to muscle weakness and decline. The authors utilized in vitro and in vivo models to investigate the mechanisms by which MET+LEU affects muscle cells, seeking to understand its role in promoting muscle health and longevity.

MET+LEU's Protective Effects on Muscle Cells

The study reveals that MET+LEU treatment can effectively prevent muscle atrophy and cellular senescence in both in vitro and in vivo models, demonstrating its potential for promoting muscle health and combating age-related decline. The authors found that MET+LEU treatment can reverse the dysregulation of proteostasis, a key process in maintaining cellular function and preventing muscle atrophy. This research suggests that MET+LEU may offer a promising therapeutic approach for mitigating age-related muscle decline and promoting healthy aging.

Rejuvenating Muscle Strength

This research provides hope for maintaining muscle strength and function as we age. The findings suggest that MET+LEU treatment may offer a promising strategy for mitigating muscle atrophy and promoting healthy aging. By understanding the mechanisms by which MET+LEU affects muscle cells, we can potentially develop new therapeutic interventions to combat age-related muscle decline and enhance overall health and well-being.

Dr. Camel's Conclusion

This research presents exciting evidence for the potential of MET+LEU treatment in preventing muscle atrophy and cellular senescence, offering a glimmer of hope for maintaining muscle strength and function as we age. The study underscores the importance of exploring innovative approaches to combatting age-related decline and promoting healthy aging. As we journey through the sands of time, it's crucial to find strategies for preserving our physical capabilities and maintaining a vibrant and active lifestyle.

Date :
  1. Date Completed 2023-04-10
  2. Date Revised 2023-10-05
Further Info :

Pubmed ID

36947713

DOI: Digital Object Identifier

PMC10085594

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Languages

English

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