Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.

Author: BavatoFrancesco, BoschOliver G, DornbiererDario A, EspositoFabrizio, LandoltHans-Peter, QuednowBoris B, SeifritzErich, StaempfliPhilipp, ZölchNiklaus

Paper Details 
Original Abstract of the Article :
Sodium oxybate (γ-hydroxybutyrate, GHB) is an endogenous GHB/GABAB receptor agonist, clinically used to promote slow-wave sleep and reduce next-day sleepiness in disorders such as narcolepsy and fibromyalgia. The neurobiological signature of these unique therapeutic effects remains elusive. Promisin...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267648/

データ提供:米国国立医学図書館(NLM)

The Neurobiology of Sleep and Wakefulness: A Camel's Journey Through the Sands of Sodium Oxybate

The study of sleep disorders is a fascinating journey through the complex interplay of brain activity, hormones, and behavior. This research explores the neurobiological effects of sodium oxybate (GHB), a drug used to treat disorders like narcolepsy and fibromyalgia. The researchers conducted a controlled trial using magnetic resonance imaging (MRI) to investigate the brain activity patterns associated with sodium oxybate administration.

The Brain's Internal Compass: A Camel's Perspective

The study found that sodium oxybate alters brain functional network connectivity, particularly between the salience network and the central executive network. These changes in brain activity are likely related to the wake-promoting effects of sodium oxybate. The study suggests that sodium oxybate may promote wakefulness by shifting the brain towards a more externally focused state.

Navigating the Desert of Sleep Disorders: A Camel's Advice

If you're struggling with sleep disorders, it's essential to consult with a healthcare professional to determine the most appropriate treatment options. Sodium oxybate can be an effective treatment for some disorders, but it's important to understand the potential side effects and risks associated with its use. Remember, finding a peaceful sleep oasis requires careful consideration and personalized medical guidance.

Dr.Camel's Conclusion

This research sheds light on the neurobiological mechanisms underlying the effects of sodium oxybate. It provides a deeper understanding of how this drug influences brain activity and contributes to its therapeutic benefits in treating sleep disorders.

Date :
  1. Date Completed 2023-06-16
  2. Date Revised 2023-06-21
Further Info :

Pubmed ID

36967111

DOI: Digital Object Identifier

PMC10267648

Related Literature

SNS
PICO Info
in preparation
Languages

English

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