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Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.
Author: BavatoFrancesco, BoschOliver G, DornbiererDario A, EspositoFabrizio, LandoltHans-Peter, QuednowBoris B, SeifritzErich, StaempfliPhilipp, ZölchNiklaus
Original Abstract of the Article :
Sodium oxybate (γ-hydroxybutyrate, GHB) is an endogenous GHB/GABAB receptor agonist, clinically used to promote slow-wave sleep and reduce next-day sleepiness in disorders such as narcolepsy and fibromyalgia. The neurobiological signature of these unique therapeutic effects remains elusive. Promisin...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267648/
データ提供:米国国立医学図書館(NLM)
The Neurobiology of Sleep and Wakefulness: A Camel's Journey Through the Sands of Sodium Oxybate
The study of sleep disorders is a fascinating journey through the complex interplay of brain activity, hormones, and behavior. This research explores the neurobiological effects of sodium oxybate (GHB), a drug used to treat disorders like narcolepsy and fibromyalgia. The researchers conducted a controlled trial using magnetic resonance imaging (MRI) to investigate the brain activity patterns associated with sodium oxybate administration.
The Brain's Internal Compass: A Camel's Perspective
The study found that sodium oxybate alters brain functional network connectivity, particularly between the salience network and the central executive network. These changes in brain activity are likely related to the wake-promoting effects of sodium oxybate. The study suggests that sodium oxybate may promote wakefulness by shifting the brain towards a more externally focused state.
Navigating the Desert of Sleep Disorders: A Camel's Advice
If you're struggling with sleep disorders, it's essential to consult with a healthcare professional to determine the most appropriate treatment options. Sodium oxybate can be an effective treatment for some disorders, but it's important to understand the potential side effects and risks associated with its use. Remember, finding a peaceful sleep oasis requires careful consideration and personalized medical guidance.
Dr.Camel's Conclusion
This research sheds light on the neurobiological mechanisms underlying the effects of sodium oxybate. It provides a deeper understanding of how this drug influences brain activity and contributes to its therapeutic benefits in treating sleep disorders.
Date :
- Date Completed 2023-06-16
- Date Revised 2023-06-21
Further Info :
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