Case report: A <i>de novo</i> ERBB3 mutation develops in a gallbladder cancer patient carrying BRCA1 mutation after effective treatment with olaparib.

Author: BaoRun-Fa, JiaZi-Yao, LauWan Yee, LiHuai-Feng, LiMao-Lan, LiXue-Chuan, LiuFa-Tao, LiuYing-Bin, LiuYun, PengShu-You, WuWen-Guang, YangJing-Xiao, ZhangFei, ZouLu

Paper Details 
Original Abstract of the Article :
Label="Background" NlmCategory="UNASSIGNED">Gallbladder cancer (GBC) is highly lethal and resistant to most chemotherapeutic drugs. GBC was reported to carry multiple genetic mutations such as TP53, K-RAS, and ERBB2/3. Here, we unexpectedly identified a patient with GBC harboring germline BRCA1 p.Ar...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034383/

データ提供:米国国立医学図書館(NLM)

A New Oasis in Gallbladder Cancer Treatment: A Case of de novo ERBB3 Mutation

Gallbladder cancer, a formidable foe, is like a treacherous desert, often resistant to conventional treatments. This case report presents an intriguing scenario of a patient with gallbladder cancer carrying a germline BRCA1 mutation, highlighting the potential for a new therapeutic approach using olaparib, a PARPi inhibitor. The case showcases the complex and dynamic nature of cancer, where the desert landscape of treatment can be constantly shifting.

A New Path Through the Desert

This case report offers a glimmer of hope in the fight against gallbladder cancer. The emergence of a de novo ERBB3 mutation after olaparib treatment suggests a potential new therapeutic strategy, a beacon of hope in the desert of this aggressive disease. The case highlights the importance of personalized medicine, where tailored treatment approaches can potentially unlock a new path to success.

A Desert of Challenges, a Journey of Hope

This case report, like a desert oasis, provides a rare moment of hope in the fight against gallbladder cancer. The emergence of a de novo ERBB3 mutation and the potential for olaparib treatment offer a new avenue for exploration, a reminder that even in the most challenging landscapes, new paths to healing can emerge.

Dr. Camel's Conclusion

This case report reminds us that the fight against cancer is a constant journey of exploration. It's like a desert caravan, navigating shifting sands and seeking new sources of hope. The study offers a valuable insight into the complex and dynamic nature of cancer, demonstrating the importance of personalized medicine and continuous research in finding new pathways to healing.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-28
Further Info :

Pubmed ID

36969051

DOI: Digital Object Identifier

PMC10034383

Related Literature

SNS
PICO Info
in preparation
Languages

English

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